Evidence map›Paper›PMID 34263161›Full record

ArticleRhinology online2020

Intranasal Corticosteroids: Patient Administration Angles and Impact of Education.

Sara Treat, Charles S Ebert, Zainab Farzal, Saikat Basu, Adam M Zanation, Brian D Thorp, Julia S Kimbell, Brent A Senior, Adam J Kimple

Open access · goldAbstract read
In one paragraph

Article in Rhinology online, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Development of a therapeutic education program for patients with chronic rhinosinusitis with nasal polyps.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sara TreatDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill.
Charles S EbertDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill.
Zainab FarzalDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill.
Saikat BasuDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill.
Adam M ZanationDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill.
Brian D ThorpDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill.
Julia S KimbellDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill.
Brent A SeniorDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill.
Adam J KimpleDepartment of Otolaryngology-Head and Neck Surgery, University of North Carolina at Chapel Hill.
University of North Carolina at Chapel Hill · US

Funding

North Carolina Translational and Clinical Science Institute (NC TraCS) KL2KL2TR002490 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEINBERGER, MORRIS · 2018 to 2022
$11.0M
Improving Topical Drug Delivery for Treatment of Chronic RhinosinusitisR01HL122154 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KIMBELL, JULIA SPENCER · 2015 to 2018
$1.5M
NCATS NIH HHS KL2 TR002490NHLBI NIH HHS R01 HL122154
6 · The paper itself

Abstract

introductionIntranasal corticosteroids sprays (INCS) are first line treatment for allergic rhinitis and are frequently used for chronic rhinosinusitis. Improperly aiming INCS increases the risk of epistaxis and may decrease the efficacy of the medication. The goal of this study was to determine how patients position INCS for drug delivery and if verbal or written instructions improve their positioning.

methodsPatients in rhinology clinics were photographed while administering a generic spray bottle. The angle of the spray bottle relative to the patients' head and a fixed background was determined.

resultsA total of 46 participants were included. The average spray angle for the right naris was 10.1° towards the septum and 67.2° below the Frankfurt Horizontal plane. The average spray angle for the left naris was 4.5° towards the septum and 62.2° below the Frankfurt horizontal plane. The angle of the spray bottle ranged from 50° toward the septum to 43° away from the septum. Only 8 patients aimed away from the septum for both nares. Patients who recalled receiving verbal and written instructions aimed the INCS bottle at the lateral wall and inferior turbinate in contrast to patients who only received one form of instruction or no instructions.

conclusionsMost patients (83%) incorrectly aim INCS when compared to current guidelines. There was statistically significant improvement in the positioning of patients who reported receiving both verbal and written instruction; however, this study highlights a greater need for patient education.

Indexed as

allergic rhinitischronic sinusitisintranasal corticosteroidspatient education

Identifiers

PMID34263161
PMCPMC8276915
OpenAlexW3099819546

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.