Evidence map›Paper›PMID 34263071›Full record

ArticleJGH open : an open access journal of gastroenterology and hepatology2021

Nonsteroidal anti-inflammatory drugs prevent gastric cancer associated with the use of proton pump inhibitors after

Junya Arai, Ryota Niikura, Yoku Hayakawa, Hiroki Sato, Takuya Kawahara, Tetsuro Honda, Kenkei Hasatani, Naohiro Yoshida, Tsutomu Nishida, Tetsuya Sumiyoshi and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JGH open : an open access journal of gastroenterology and hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Environmental factors in gastric carcinogenesis and preventive intervention strategies.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 1 country.

Junya AraiDepartment of Gastroenterology, Graduate School of Medicine The University of Tokyo Bunkyo City Tokyo Japan.ORCID https://orcid.org/0000-0002-4905-7046
Ryota NiikuraDepartment of Gastroenterology, Graduate School of Medicine The University of Tokyo Bunkyo City Tokyo Japan.ORCID https://orcid.org/0000-0001-5047-6195
Yoku HayakawaDepartment of Gastroenterology, Graduate School of Medicine The University of Tokyo Bunkyo City Tokyo Japan.ORCID https://orcid.org/0000-0002-3988-2499
Hiroki SatoDepartment of Gastroenterology, Graduate School of Medicine The University of Tokyo Bunkyo City Tokyo Japan.
Takuya KawaharaClinical Research Promotion Center The University of Tokyo Hospital Bunkyo City Tokyo Japan.
Tetsuro HondaDepartment of Gastroenterology Nagasaki Harbor Medical Center Nagasaki-shi Nagasaki Japan.
Kenkei HasataniDepartment of Gastroenterology Fukui Prefectural Hospital Fukui-shi Fukui Japan.
Naohiro YoshidaDepartment of Gastroenterology Ishikawa Prefectural Central Hospital Kanazawa-shi Ishikawa Japan.
Tsutomu NishidaDepartment of Gastroenterology Toyonaka Municipal Hospital Toyonaka-shi Osaka Japan.ORCID https://orcid.org/0000-0003-4037-9003
Tetsuya SumiyoshiDepartment of Gastroenterology Tonan Hospital Sapporo-shi Hokkaido Japan.
Shu KiyotokiDepartment of Gastroenterology Shuto General Hospital Yanai-shi Yamaguchi Japan.
Takashi IkeyaDepartment of Gastroenterology St. Luke's International Hospital Chuo-ku Tokyo Japan.
Masahiro AraiDepartment of Gastroenterology Nerima Hikarigaoka Hospital Nerima-ku Tokyo Japan.
Nobumi SuzukiDepartment of Gastroenterology, Graduate School of Medicine The University of Tokyo Bunkyo City Tokyo Japan.
Yosuke TsujiDepartment of Gastroenterology, Graduate School of Medicine The University of Tokyo Bunkyo City Tokyo Japan.
Atsuo YamadaDepartment of Gastroenterology, Graduate School of Medicine The University of Tokyo Bunkyo City Tokyo Japan.ORCID https://orcid.org/0000-0003-4314-7777
Kazuhiko KoikeDepartment of Gastroenterology, Graduate School of Medicine The University of Tokyo Bunkyo City Tokyo Japan.
Bunkyo University · JPFukui Prefectural Hospital · JPIshikawa Prefectural Central Hospital · JPNagasaki Medical Center · JPNerima General Hospital · JPShuto General Hospital · JPSt. Luke's International Hospital · JPTonan Hospital · JPToyonaka Municipal Hospital · JPUniversity of Tokyo Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimProton pump inhibitors (PPIs) are a potential cause of gastric carcinogenesis after

methodsA multicenter retrospective cohort study was conducted. Patients who used a PPI (≥30 days) after

resultsDuring the mean follow-up period of 2.38 years, 1.13% (31/2431) of all patients developed gastric cancer. The cumulative incidence of gastric cancer in PPI users was 0.25% at 1 year, 0.51% at 3 years, and 1.09% at 5 years in the NSAID users and 0.89% at 1 year, 2.32% at 3 years, and 3.61% at 5 years in nonusers. NSAIDs were associated with a lower gastric cancer risk (adjusted hazard ratio = 0.28,

conclusionNSAIDs were associated with a 60% decrease in the gastric cancer incidence in

Indexed as

COX2 inhibitorsgastric cancerHelicobacter pyloriNSAIDsproton pump inhibitor

Identifiers

PMID34263071
PMCPMC8264245
OpenAlexW3166548397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.