ArticleFrontiers in nutrition2021
Selenium Status Is Associated With Insulin Resistance Markers in Adults: Findings From the 2013 to 2018 National Health and Nutrition Examination Survey (NHANES).
Article in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- The association between blood selenium and metabolic syndrome in adults: a systematic review and dose-response meta-analysis of epidemiologic studies.Frontiers in nutrition · 2024Pooled it
- Pooled it
- Pooled it
- Impact of organic selenium supplementation on glycaemic control and quality of life in patients with diabetic neuropathy: a randomized placebo-controlled trial.European journal of nutrition · 2026Trial
- Inflammation Mediates the Associations Between Selenium Status and Glucose Metabolism in Chinese Females Over 45 Years Old: a National Cross-Sectional Study.Biological trace element research · 2026Article
- Association of Serum Selenium with Pro-Atherogenic Adhesion Molecules, Inflammatory Cytokines and Carotid Intima-Media Thickness in Patients with Metabolic Syndrome.Biological trace element research · 2026Article
- Associations of metal mixtures with insulin resistance and glucose homeostasis in U.S. adults from the NHANES 2011-2018.Scientific reports · 2026Article
- Activation of the De Novo Serine Synthesis Pathway and Disruption of Insulin Signaling Induced by Supplemental SeMet in Vitro.Biological trace element research · 2025Article
- Differential association of selenium exposure with insulin resistance and β-cell function in middle age and older adults.Nutrition & diabetes · 2025Article
- Unraveling the Link: Mendelian Randomization Reveals Causal Relationship Between Selenium and Metabolic Syndrome.Biological trace element research · 2025Article
- A cross-sectional analysis of dietary selenium intake and type 2 diabetes risk in adults: insights from NHANES 2011-2016.Frontiers in nutrition · 2025Article
- Increased Expression of PHGDH Under High-Selenium Stress In Vivo.Biological trace element research · 2024Article
- Influence of smoking status on the relationship between serum selenium and cause-specific mortality in US adults.Scientific reports · 2024Article
- Selenium Species in Diabetes Mellitus Type 2.Biological trace element research · 2024Review
- Serum selenium and fasting blood glucose: a cross-sectional study in women of different menopause status.BMC women's health · 2024Article
- High Concentrations of Se Inhibited the Growth of Rice Seedlings.Plants (Basel, Switzerland) · 2024Article
- Composite dietary antioxidant index is associated with reduced prevalence of metabolic syndrome but not mortality in metabolic syndrome: Results from NHANES 2001-2018.Preventive medicine reports · 2024Article
- Selenium Status of Southern Africa.Nutrients · 2024Review
- Selenium Concentration Is Positively Associated with Triglyceride-Glucose Index and Triglyceride Glucose-Body Mass Index in Adults: Data from NHANES 2011-2018.Biological trace element research · 2024Article
- Higher Levels of Blood Selenium are Associated with Higher Levels of Serum Lipid Profile in US Adults with CKD: Results from NHANES 2013-2018.Biological trace element research · 2023Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although literature has been consistently showing an increased risk of type 2 diabetes (T2DM) in populations with high exposure to selenium, there is a lack of information quantifying the association between diabetes-related markers and the nutritional status of selenium. Therefore, we aimed to investigate the association between blood selenium concentration and glucose markers in a representative sample of the US population, which is known to have moderate to high exposure to selenium. This cross-sectional analysis included 4,339 participants ≥18 years from the 2013 to 2018 National Health and Nutrition Examination Survey (NHANES). All participants were assessed for whole blood selenium concentration, fasting plasma insulin and glucose, HbA1c, and HOMA-IR (Homeostatic Model Assessment for Insulin Resistance). In this cohort, all participants presented with adequate selenium status [196.2 (SD: 0.9) μg/L] and 867 (15%) had diabetes mellitus. Selenium was positively associated with insulin, glucose and HOMA-IR in models adjusted for age and sex. When the models were further adjusted for smoking status, physical activity, metabolic syndrome and BMI, the associations with insulin and HOMA-IR remained but the association with glucose was no longer significant. A 10 μg/L increase in selenium was associated with 1.5% (95% CI: 0.4-2.6%) increase in insulin and 1.7% (95% CI: 0.5-2.9%) increase in HOMA-IR in fully adjusted models. There was no evidence of an association between selenium and diabetes prevalence. Our findings corroborate the notion that selenium supplementation should not be encouraged in populations with high dietary intake of selenium.
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