Evidence map›Paper›PMID 34262893›Full record

ArticleFrontiers in chemistry2021

Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions.

Yeting Guo, Jianxi Ying, Dongru Sun, Yumeng Zhang, Minyang Zheng, Ruiwen Ding, Yan Liu, Yufen Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. LC/MS Q-TOF Metabolomic Investigation of Amino Acids and Dipeptides inJournal of agricultural and food chemistry · 2022
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yeting GuoInstitute of Drug Discovery Technology, Ningbo University, Ningbo, China.
Jianxi YingInstitute of Drug Discovery Technology, Ningbo University, Ningbo, China.
Dongru SunInstitute of Drug Discovery Technology, Ningbo University, Ningbo, China.
Yumeng ZhangDepartment of Chemical Biology, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.
Minyang ZhengInstitute of Drug Discovery Technology, Ningbo University, Ningbo, China.
Ruiwen DingInstitute of Drug Discovery Technology, Ningbo University, Ningbo, China.
Yan LiuDepartment of Chemical Biology, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.
Yufen ZhaoInstitute of Drug Discovery Technology, Ningbo University, Ningbo, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyclic dipeptides (DKPs) are peptide precursors and chiral catalysts in the prebiotic process. This study reports proline-containing DKPs that were spontaneously obtained from linear dipeptides under an aqueous solution. Significantly, the yields of DKPs were affected by the sequence of linear dipeptides and whether the reaction contains trimetaphosphate. These findings provide the possibility that DKPs might play a key role in the origin of life.

Indexed as

aqueous solutioncyclic dipeptidelinear dipeptideorigin of lifeprebiotic synthesis

Identifiers

PMID34262893
PMCPMC8273163

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.