Evidence map›Paper›PMID 34262786›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

Forearm muscle mitochondrial capacity and resting oxygen uptake: Relationship to symptomatic fatigue in persons with multiple sclerosis.

Elizabeth M DePauw, Mitra Rouhani, Aidan M Flanagan, Alexander V Ng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Elizabeth M DePauwProgram in Exercise Science, Department of Physical Therapy, Marquette University, Milwaukee, WI, USA.ORCID https://orcid.org/0000-0003-0805-4081
Mitra RouhaniExercise and Rehabilitation Science program, Department of Physical Therapy, Marquette University, Milwaukee, WI, USA.ORCID https://orcid.org/0000-0002-9066-4403
Aidan M FlanaganProgram in Exercise Science, Department of Physical Therapy, Marquette University, Milwaukee, WI, USA.
Alexander V NgProgram in Exercise Science, Department of Physical Therapy, Marquette University, Milwaukee, WI, USA.ORCID https://orcid.org/0000-0002-0742-9825
Marquette University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMitochondrial dysfunction has been implicated in the pathogenesis of multiple sclerosis (MS). Whether mitochondrial alterations are a function of ambulatory dysfunction or are of a non-ambulatory systemic nature is unclear.

objectiveTo compare oxidative capacity, and rest muscle oxygen consumption (mVO

methodsNear infra-red spectroscopy was used to measure oxidative capacity of the wrist flexors in PwMS (n = 16) and CON (n = 13). Oxidative capacity was indicated by the time constant (TC) of mVO

resultsTC of mVO

conclusionOxidative capacity was lower in the wrist flexors of PwMS, possibly indicating a systemic component of the disease. Within PwMS, rest mVO

Indexed as

fatiguegaitMultiple sclerosismuscle oxidative capacityupper extremity

Identifiers

PMID34262786
PMCPMC8246512
OpenAlexW3175805021

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.