ArticleTherapeutic advances in infectious disease
An exercise intervention alters stool microbiota and metabolites among older, sedentary adults.
Article in Therapeutic advances in infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise for Healthy Aging: The Impact of HIV and Aging on Physical Function and the Somatopause
The Effects of a 12-week Combined Exercise Intervention on the Gut Microbiome of Older Adults
Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Global Microbiome: Core and Unique Signatures Across Diverse Populations.International journal of molecular sciences · 2026Pooled it
- Physical activity, sedentary behavior and microbiome: A systematic review and meta-analysis.Journal of science and medicine in sport · 2024Pooled it
- Pooled it
- Systematic Review of the Effects of Exercise and Physical Activity on the Gut Microbiome of Older Adults.Nutrients · 2022Pooled it
- Eight Weeks ofNutrients · 2023Trial
- Is There a Relationship Between the Gut Microbiome and the Functional Capabilities of Skeletal Muscle? A Narrative Review.Nutrients · 2026Review
- Short-Chain Fatty Acids: Bridging Gut Microbiota and Systemic Aging-Mechanisms, Interventions, and Current Challenges.Metabolites · 2026Review
- Article
- Gut microbiota-derived metabolites as immune modulators in aging and age-related chronic inflammatory diseases.Ageing research reviews · 2026Review
- Gut microbiota mediates the beneficial effects of exercise on autism-like behaviors.BMC microbiology · 2026Article
- Review
- Impact of Exercise Regimens on Childhood Obesity Through Gut Microbiota Regulation: A Systematic Review.International journal of endocrinology · 2026Review
- Functional signatures of the gut microbiome in middle-aged regular runners: insights from a metagenomic study.Frontiers in physiology · 2026Article
- The brain-gut-muscle axis: a mechanism for exercise-mediated protection in brain aging.Frontiers in aging neuroscience · 2026Review
- Exercise attenuates the hallmarks of aging: Novel perspectives.Journal of sport and health science · 2025Review
- Physical Activity, Gut Microbiota, and the Risk of Dyslipidemia in a Community-Based Cohort Study.Journal of the American Heart Association · 2025Article
- From dysbiosis to longevity: a narrative review into the gut microbiome's impact on aging.Journal of biomedical science · 2025Review
- Mechanisms of exercise in preventing cardiovascular diseases: Insights from gut microbiota characteristics in pathological states of cardiovascular diseases.Reviews in endocrine & metabolic disorders · 2025Review
- Assessing the gut microbiota composition in older adults: connections to physical activity and healthy ageing.GeroScience · 2025Observational
- Fecal Microbiota and Associated Metabolites Are Minimally Affected by Ten Weeks of Resistance Training in Younger and Older Adults.Sports (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPhysiologic aging has been associated with gut dysbiosis. Although short exercise interventions have been linked to beneficial changes in gut microbiota in younger adults, limited data are available from older populations. We hypothesized that exercise would produce beneficial shifts in microbiota and short-chain fatty acid (SCFA) levels in older persons.
methodsStool samples were collected before and at completion of a supervised 24-week cardiovascular and resistance exercise intervention among 50-75-year-old participants. SCFA levels were analyzed by gas chromatography and microbiome by 16S rRNA gene sequencing. Negative binomial regression models compared pre- and post-differences using false discovery rates for multiple comparison.
resultsA total of 22 participants provided pre-intervention samples; 15 provided samples at study completion. At baseline, the majority of participants were men (95%), mean age 58.0 (8.8) years, mean body mass index 27.4 (6.4) kg/m
conclusionOur pilot study suggested that an exercise intervention is associated with changes in the microbiome of older adults and a key bacterial metabolite, butyrate. Although some of these changes could potentially reverse age-related dysbiosis, future studies are required to determine the contribution of changes to the microbiome in the beneficial effect of exercise on overall health of older adults. Clinical Trials NCT02404792.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.