Evidence map›Paper›PMID 34262748›Full record

ArticleFood science & nutrition2021

10-Gingerol alleviates hypoxia/reoxygenation-induced cardiomyocyte injury through inhibition of the Wnt5a/Frizzled-2 pathway.

Bin Zheng, Jiaying Qi, Panpan Liu, Muqing Zhang, Yuanyuan Zhang, Yucong Xue, Xue Han, Shan Xu, Li Chu

Open access · hybridAbstract read
In one paragraph

Article in Food science & nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Bin ZhengSchool of Pharmacy Hebei University of Chinese Medicine Shijiazhuang China.
Jiaying QiSchool of Pharmacy Hebei University of Chinese Medicine Shijiazhuang China.
Panpan LiuSchool of Pharmacy Hebei University of Chinese Medicine Shijiazhuang China.
Muqing ZhangSchool of Pharmacy Hebei University of Chinese Medicine Shijiazhuang China.
Yuanyuan ZhangSchool of Pharmacy Hebei University of Chinese Medicine Shijiazhuang China.
Yucong XueSchool of Pharmacy Hebei University of Chinese Medicine Shijiazhuang China.
Xue HanSchool of Pharmacy Hebei University of Chinese Medicine Shijiazhuang China.
Shan XuAffiliated Hospital Hebei University of Chinese Medicine Shijiazhuang China.
Li ChuSchool of Pharmacy Hebei University of Chinese Medicine Shijiazhuang China.ORCID https://orcid.org/0000-0002-6301-2709
Hebei University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

10-Gingerol (10-Gin), an active ingredient extracted from ginger, has been reported to have beneficial effects on the cardiovascular system. However, 10-Gin has not been proved to offer protection against cardiomyocyte injury induced by hypoxia/reoxygenation (H/R). This study aimed to investigate the protective effects of 10-Gin against H/R-induced injury and its potential mechanisms in cardiomyocytes. A H/R injury model of H9c2 cardiomyocytes was established using 600 μmol/L CoCl

Indexed as

10‐GingerolCoCl2H9c2 cardiomyocytehypoxia/reoxygenationintracellular Ca2+ overloadWnt5a/Frizzled‐2 pathway

Identifiers

PMID34262748
PMCPMC8269582
OpenAlexW3166348632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.