ArticleFood science & nutrition2021
Chain length-dependent inulin alleviates diet-induced obesity and metabolic disorders in mice.
Article in Food science & nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Dietary inulin modulates pork quality and systemic health via gut microbiome and metabolome changes in finishing pigs.Animal microbiome · 2026Article
- The gut microbiota-short-chain fatty acid-inflammation axis in Parkinson's disease motor dysfunction: mechanisms and future of dietary interventions.Frontiers in neurology · 2026Review
- Inulin Reverses Intestinal Mrp2 Downregulation in a Diet-Induced Obesity Mouse Model: Role of Intestinal Microbiota as a Pivotal Modulator.Pharmaceutics · 2025Article
- Complex Probiotics Suppress Inflammation by Regulating Intestinal Metabolites in Kittens.Animals : an open access journal from MDPI · 2025Article
- Traditional Chinese medicine to improve immune imbalance of asthma: focus on the adjustment of gut microbiota.Frontiers in microbiology · 2024Review
- The impact of high polymerization inulin on body weight reduction in high-fat diet-induced obese mice: correlation with cecalFrontiers in microbiology · 2024Article
- Differential effects of plant-based flours on metabolic homeostasis and the gut microbiota in high-fat fed rats.Nutrition & metabolism · 2023Article
- Amelioration of Obesity-Related Disorders in High-Fat Diet-Fed Mice following Fecal Microbiota Transplantation from Inulin-Dosed Mice.Molecules (Basel, Switzerland) · 2023Article
- Inulin reduces visceral adipose tissue mass and improves glucose tolerance through altering gut metabolites.Nutrition & metabolism · 2022Article
- Chain length-dependent inulin alleviates diet-induced obesity and metabolic disorders in mice.Food science & nutrition · 2021Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary fiber is regarded to improve host metabolic disorders through modulating gut microbiota. The study was to investigate the effects of inulin with different degree of polymerization (DP) on adiposity, related metabolic syndrome, and the possible mechanisms from the points of gut microbiota and metabolite changes. C57Bl/6J male mice were randomly allocated to normal diet (ND) group, high-fat diet (HFD) group, two HFD groups with short-chain inulin (HFD-S) and medium and long-chain inulin (HFD-ML) for 8 weeks. Compared with HFD treatment, ML-inulin supplementation significantly decreased weight gain, hepatic steatosis, chronic inflammation, and increased insulin sensitivity, energy expenditure and thermogenesis. This could be mimicked by S-inulin supplementation to some degree although it is not as effective as ML inulin. Also, mice treated with S and ML inulin had a remarkable alternation in the composition of gut microbiota and increased the production of short-chain fatty acids (SCFAs). However, reduced serum levels of essential fatty acids, vitamins B1 and B3 by HFD were further decreased by both inulin supplementations. ML inulin can prevent HFD-induced obesity and the associated metabolic disorders, and may be used as novel gut microbiota modulator to prevent HFD-induced gut dysbiosis and metabolic disorders.
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