Evidence map›Paper›PMID 34262697›Full record

ArticleRSC advances2020

A fluorescent target-guided Paal-Knorr reaction.

Sachin B Wagh, Vladimir Maslivetc, James J La Clair, Alexander Kornienko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Lessons in Organic Fluorescent Probe Discovery.Chembiochem : a European journal of chemical biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Sachin B WaghThe Department of Chemistry and Biochemistry, Texas State University, San Marcos 78666, USA.ORCID 0000-0002-4123-5143
Vladimir MaslivetcThe Department of Chemistry and Biochemistry, Texas State University, San Marcos 78666, USA.ORCID 0000-0002-6290-0691
James J La ClairXenobe Research Institute, P. O. Box 3052, San Diego, USA.ORCID 0000-0001-6500-4107
Alexander KornienkoThe Department of Chemistry and Biochemistry, Texas State University, San Marcos 78666, USA.ORCID 0000-0003-2041-7367
Texas State University · USXenobe Research Institute · US

Funding

Tandem Discovery of Drug Leads and Targets via Paal-Knorr reactionR21GM131717 · NIGMS · TEXAS STATE UNIVERSITY · PI KORNIENKO, ALEXANDER, LA CLAIR, JAMES J · 2019 to 2020
$374k
NIGMS NIH HHS R21 GM131717
6 · The paper itself

Abstract

It has become increasingly apparent that high-diversity chemical reactions play a significant role in the discovery of bioactive small molecules. Here, we describe an expanse of this paradigm, combining a 'target-guided synthesis' concept with Paal-Knorr chemistry applied to the preparation of fluorescent ligands for human prostaglandin-endoperoxide synthase (COX-2).

Identifiers

PMID34262697
PMCPMC8276889
OpenAlexW3092028780

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.