Evidence map›Paper›PMID 34262686›Full record

ArticleJournal of tissue engineering

Development of a Bioartificial Vascular Pancreas.

Edward X Han, Juan Wang, Mehmet Kural, Bo Jiang, Katherine L Leiby, Nazar Chowdhury, George Tellides, Richard G Kibbey, Jeffrey H Lawson, Laura E Niklason

Open access · goldAbstract read
In one paragraph

Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Islet Cell Replacement and Regeneration for Type 1 Diabetes: Current Developments and Future Prospects.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025
    Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Edward X HanDepartment of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-5989-1747
Juan WangVascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, USA.
Mehmet KuralVascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, USA.
Bo JiangDepartment of Surgery, Yale School of Medicine, New Haven, CT, USA.
Katherine L LeibyDepartment of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT, USA.
Nazar ChowdhuryMolecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA.
George TellidesVascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, USA.
Richard G KibbeyDepartment of Internal Medicine (Endocrinology), Yale University, New Haven, CT, USA.
Jeffrey H LawsonDepartment of Surgery, Duke University, Durham, NC, USA.
Laura E NiklasonDepartment of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT, USA.
Yale University · USDuke University · US

Funding

Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold, GERALD I SHULMAN · 1993 to 2026
$44.0M
Mitochondrial ADP privation: A unifying model for glucose-induced insulin secretion.R01DK127637 · NIDDK · YALE UNIVERSITY · PI KIBBEY, RICHARD G, MERRINS, MATTHEW J. · 2021 to 2025
$3.4M
Biologically Selective Drug-Eluting StentR01HL148819 · NHLBI · YALE UNIVERSITY · PI SALTZMAN, WILLIAM · 2019 to 2022
$2.7M
NHLBI NIH HHS R01 HL148819NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R01 DK127637
6 · The paper itself

Abstract

Transplantation of pancreatic islets has been shown to be effective, in some patients, for the long-term treatment of type 1 diabetes. However, transplantation of islets into either the portal vein or the subcutaneous space can be limited by insufficient oxygen transfer, leading to islet loss. Furthermore, oxygen diffusion limitations can be magnified when islet numbers are increased dramatically, as in translating from rodent studies to human-scale treatments. To address these limitations, an islet transplantation approach using an acellular vascular graft as a vascular scaffold has been developed, termed the BioVascular Pancreas (BVP). To create the BVP, islets are seeded as an outer coating on the surface of an acellular vascular graft, using fibrin as a hydrogel carrier. The BVP can then be anastomosed as an arterial (or arteriovenous) graft, which allows fully oxygenated arterial blood with a pO

Indexed as

Cell-based therapeuticsIslet transplantationTissue engineeringType 1 diabetesVascular graft

Identifiers

PMID34262686
PMCPMC8243137
OpenAlexW3174558844

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.