Evidence map›Paper›PMID 34262560›Full record

ArticleFrontiers in immunology2021

LYG1 Deficiency Attenuates the Severity of Acute Graft-Versus-Host Disease

Huihui Liu, Zhengyu Yu, Bo Tang, Shengchao Miao, Chenchen Qin, Yuan Li, Zeyin Liang, Yongjin Shi, Yang Zhang, Qingya Wang and 4 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 18 citations in OpenAlex.

  1. Frontiers in immunology · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Huihui LiuDepartment of Hematology, Peking University First Hospital, Beijing, China.
Zhengyu YuDepartment of Hematology, Peking University First Hospital, Beijing, China.
Bo TangDepartment of Hematology, Peking University First Hospital, Beijing, China.
Shengchao MiaoDepartment of Hematology, Peking University First Hospital, Beijing, China.
Chenchen QinDepartment of Hematology, Peking University First Hospital, Beijing, China.
Yuan LiDepartment of Hematology, Peking University First Hospital, Beijing, China.
Zeyin LiangDepartment of Hematology, Peking University First Hospital, Beijing, China.
Yongjin ShiDepartment of Hematology, Peking University First Hospital, Beijing, China.
Yang ZhangDepartment of Hematology, Peking University First Hospital, Beijing, China.
Qingya WangDepartment of Hematology, Peking University First Hospital, Beijing, China.
Miao YanDepartment of Hematology, Peking University First Hospital, Beijing, China.
Zhengyang SongDepartment of Hematology, Peking University First Hospital, Beijing, China.
Hanyun RenDepartment of Hematology, Peking University First Hospital, Beijing, China.
Yujun DongDepartment of Hematology, Peking University First Hospital, Beijing, China.
Peking University · CNPeking University First Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute graft-versus-host disease (aGVHD) is a lethal complication after allogeneic hematopoietic stem cell transplantation. The mechanism involves the recognition of host antigens by donor-derived T cells which induces augmented response of alloreactive T cells. In this study, we characterized the role of a previously identified novel classical secretory protein with antitumor function-LYG1 (Lysozyme G-like 1), in aGVHD. LYG1 deficiency reduced the activation of CD4

Indexed as

AllograftsAnimalsCell Line, TumorCell PolarityDisease Models, AnimalGlycoside HydrolasesGraft vs Host DiseaseGraft vs Tumor EffectHematopoietic Stem Cell TransplantationHumansInterferon-gammaLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutGlycoside HydrolasesIFNG protein, mouseInterferon-gammaLYG1 protein, mouseMuramidaseRecombinant ProteinsaGVHDallogeneic CD4+ T cellsalloreactivityLYG1Th1 cellsTreg cells

Identifiers

PMID34262560
PMCPMC8273552
OpenAlexW3177131303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.