Evidence map›Paper›PMID 34262547›Full record

ArticleFrontiers in microbiology2021

Substitutions at Loop Regions of TMUV E Protein Domain III Differentially Impair Viral Entry and Assembly.

Tao Hu, Zhen Wu, Shaoxiong Wu, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 1 institution in 1 country.

Tao HuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Zhen WuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Shaoxiong WuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Mingshu WangResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Renyong JiaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Dekang ZhuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Mafeng LiuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Xinxin ZhaoResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Qiao YangResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Ying WuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Shaqiu ZhangResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Juan HuangResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Sai MaoResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Xumin OuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Qun GaoResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Di SunResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Yunya LiuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Ling ZhangResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
YanLing YuResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Shun ChenResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Anchun ChengResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Sichuan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flavivirus envelope protein (E) plays an important role in cellular infection, especially in virulence and antigenicity. E domain III of Tembusu virus (TMUV) is highly conserved among flaviviruses and contains four loop regions. However, the functions of the loop regions of TMUV E domain III in the viral life cycle have not yet been discovered. In this study, using a reverse genetics system, we performed site-directed mutagenesis on loops I, II, III, and IV of TMUV E domain III. Mutant 6 (S388A.G389A.K390A) showed better proliferation than the wild-type virus, while mutants 1-5 exhibited decreased

Indexed as

envelope proteinloops of domain IIITMUVvirus assemblyvirus entry

Identifiers

PMID34262547
PMCPMC8273266
OpenAlexW3173422238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.