Evidence map›Paper›PMID 34262529›Full record

ArticleFrontiers in endocrinology2021

Misdiagnosis of Paget's Disease of Bone in a Congenital Generalized Lipodystrophy Patient: Case Report.

Erika Bastos Lima Freire, Mayara Ponte Madeira, Grayce Ellen da Cruz Paiva Lima, Virginia Oliveira Fernandes, Lindenberg Barbosa Aguiar, João Paulo Uchoa Fontenele, Ana Paula Dias Rangel Montenegro, Thyciara Fontenele Marques, Renan Galvão Ozório, Catarina Brasil d'Alva and 1 more

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In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Erika Bastos Lima FreireClinical Research Unit, Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Brazil.
Mayara Ponte MadeiraClinical Research Unit, Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Brazil.
Grayce Ellen da Cruz Paiva LimaClinical Research Unit, Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Brazil.
Virginia Oliveira FernandesClinical Research Unit, Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Brazil.
Lindenberg Barbosa AguiarDepartment of Radiology, Federal University of Ceará, Fortaleza, Brazil.
João Paulo Uchoa FontenelePathology Department, Dr. Cesar Cals de Oliveira General Hospital, Fortaleza, Brazil.
Ana Paula Dias Rangel MontenegroClinical Research Unit, Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Brazil.
Thyciara Fontenele MarquesHealth Sciences Center, Medical Faculty of Juazeiro do Norte, Juazeiro do Norte, Brazil.
Renan Galvão OzórioDepartment of Clinical Medicine, Federal University of Ceará, Fortaleza, Brazil.
Catarina Brasil d'AlvaClinical Research Unit, Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Brazil.
Renan Magalhães MontenegroClinical Research Unit, Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Brazil.
Universidade Federal do Ceará · BRHospital Universitário Walter Cantídio · BRCentro Universitário do Norte · BRHospital Geral de Fortaleza · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paget's disease of bone (PDB) is a common skeleton disorder in which the diagnosis is suggested by radiological analyses. Congenital generalized lipodystrophy (CGL) is a rare, but a radiologic differential diagnosis of Paget's disease. Patients present total or almost total lack of subcutaneous adipose tissue, leptin deficiency, and precocious ectopic lipid accumulation, which lead to intense insulin resistance, poorly controlled diabetes mellitus, and hypertriglyceridemia. CGL subtypes 1 and 2 present sclerosis and osteolytic lesions that can resemble "pagetic" lesions. The clinical correlation is, therefore, essential. We report a CGL patient with bone lesions in which the radiographic findings led to a misdiagnosis of PDB. This case report brings awareness to CGL, a life-threating condition. Its early recognition is essential to avoid clinical complications and premature death. Therefore, it is important to consider CGL as PDB's differential diagnosis, especially in countries with high prevalence of this rare disease, such as Brazil.

Indexed as

AdultDiagnosis, DifferentialDiagnostic ErrorsHumansLipodystrophy, Congenital GeneralizedMaleOsteitis DeformansBerardinelli-Seip syndromeBonecase reportcongenital generalized Lipodystrophy patientLipodystrophyPaget’s Disease of bone

Identifiers

PMID34262529
PMCPMC8273302
OpenAlexW3176079753

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.