ArticleFrontiers in aging neuroscience2021
Frontal White Matter Hyperintensities and Executive Functioning Performance in Older Adults.
Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Accelerated brain aging and anterior white matter hyperintensity burden in chronic post-stroke aphasia: a lesion-aware MRI analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Physical function domain associations with cognitive domains in community-dwelling older adults.medRxiv : the preprint server for health sciences · 2026Article
- Cross-organ MRI to assess the relationship between cardiac traits and cerebral white matter hyperintensity volumes.Communications medicine · 2026Article
- Impact of regional white matter hyperintensity patterns on cognitive trajectories in NACC.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Executive Functioning Training for Reducing Cognitive Intra-Individual Variability in People Living with HIV: A Pilot Randomized, Controlled Trial Protocol.Nursing (Auckland, N.Z.) · 2025Article
- Semantic processing in older adults is associated with distributed neural activation which varies by association and abstractness of words.GeroScience · 2024Article
- Deficits in memory metacognitive efficiency in late adulthood are related to distinct brain profile.Memory (Hove, England) · 2024Article
- Effect of the duration of hypertension on white matter structure and its link with cognition.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Article
- The brain, gut, and bladder health nexus: A conceptual model linking stress and mental health disorders to overactive bladder in women.Neurourology and urodynamics · 2024Article
- Automated brain segmentation and volumetry in dementia diagnostics: a narrative review with emphasis on FreeSurfer.Frontiers in aging neuroscience · 2024Review
- Altered age-related alpha and gamma prefrontal-occipital connectivity serving distinct cognitive interference variants.NeuroImage · 2023Article
- Ten-Year Cardiovascular Disease Risk Score and Cognitive Function Among Older Adults: The National Health and Nutrition Examination Survey 2011 to 2014.Journal of the American Heart Association · 2023Article
- White matter changes underlie hypertension-related cognitive decline in older adults.NeuroImage. Clinical · 2023Review
- Socioeconomic status impacts cognitive and socioemotional processes in healthy ageing.Scientific reports · 2022Article
- Cingulo-opercular and frontoparietal control network connectivity and executive functioning in older adults.GeroScience · 2022Article
- Pathological functional impairment: Neuropsychological correlates of the shared variance between everyday functioning and brain volumetrics.Frontiers in aging neuroscience · 2022Article
- Probing cognitive reserve with resting state functional connectivity in subcortical ischemic vascular cognitive impairment.Journal of Alzheimer's disease reportsArticle
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Authors and funding
18 authors at 3 institutions in 1 country.
Funding
Abstract
Frontal lobe structures decline faster than most other brain regions in older adults. Age-related change in the frontal lobe is associated with poorer executive function (e.g., working memory, switching/set-shifting, and inhibitory control). The effects and presence of frontal lobe white matter hyperintensities (WMH) on executive function in normal aging is relatively unknown. The current study assessed relationships between region-specific frontal WMH load and cognitive performance in healthy older adults using three executive function tasks from the NIH Toolbox (NIHTB) Cognition Battery. A cohort of 279 healthy older adults ages 65-88 completed NIHTB and 3T T1-weighted and FLAIR MRI. Lesion Segmentation Toolbox quantified WMH volume and generated lesion probability maps. Individual lesion maps were registered to the Desikan-Killiany atlas in FreeSurfer 6.0 to define regions of interest (ROI). Independent linear regressions assessed relationships between executive function performance and region-specific WMH in frontal lobe ROIs. All models included age, sex, education, estimated total intracranial volume, multi-site scanner differences, and cardiovascular disease risk using Framingham criteria as covariates. Poorer set-shifting performance was associated with greater WMH load in three frontal ROIs including bilateral superior frontal (left β = -0.18, FDR-
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.