Evidence map›Paper›PMID 34262429›Full record

ArticleFrontiers in neuroscience2021

Ethanol-Dependent Synthesis of Salsolinol in the Posterior Ventral Tegmental Area as Key Mechanism of Ethanol's Action on Mesolimbic Dopamine.

Valentina Bassareo, Roberto Frau, Riccardo Maccioni, Pierluigi Caboni, Cristina Manis, Alessandra T Peana, Rossana Migheli, Simona Porru, Elio Acquas

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Role of Metabolism on Alcohol Preference, Addiction, and Treatment.Current topics in behavioral neurosciences · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Current View on the Mechanisms of Alcohol-Mediated Toxicity.International journal of molecular sciences · 2021
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Valentina BassareoCenter of Excellence for the Study of Neurobiology of Addiction, University of Cagliari, Cagliari, Italy.
Roberto FrauDepartment of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Riccardo MaccioniDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Pierluigi CaboniDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Cristina ManisDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Alessandra T PeanaDepartment of Chemistry and Pharmacy, University of Sassari, Sassari, Italy.
Rossana MigheliDepartment of Experimental Medical and Surgical Sciences, University of Sassari, Sassari, Italy.
Simona PorruDepartment of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Elio AcquasCenter of Excellence for the Study of Neurobiology of Addiction, University of Cagliari, Cagliari, Italy.
University of Cagliari · ITUniversity of Sassari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal consumption of ethanol, the ingredient responsible for alcoholic drinks' addictive liability, causes millions of deaths yearly. Ethanol's addictive potential is triggered through activation, by a still unknown mechanism, of the mesolimbic dopamine (DA) system, part of a key motivation circuit, DA neurons in the posterior ventral tegmental area (pVTA) projecting to the ipsilateral nucleus accumbens shell (AcbSh). The present

Indexed as

acetaldehydebrain microdialysisdopamineethanolnucleus accumbens shellposterior ventral tegmental areasalsolinolμ opioid receptors

Identifiers

PMID34262429
PMCPMC8273231
OpenAlexW3175606983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.