ArticleReproductive medicine and biology2021
Analysis of vaginal and endometrial microbiota communities in infertile women with a history of repeated implantation failure.
Article in Reproductive medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Endometrial microbiota-targeted therapies for chronic endometritis-associated recurrent implantation failure and their impact on IVF outcomes: A systematic review and methodological quality assessment.Acta obstetricia et gynecologica Scandinavica · 2026Pooled it
- Distinctive reproductive tract microbial characteristics associated with infertility in women: a systematic review and meta-analysis.Frontiers in cellular and infection microbiology · 2026Pooled it
- Causes of embryo implantation failure: A systematic review and metaanalysis of procedures to increase embryo implantation potential.Frontiers in endocrinology · 2024Pooled it
- The role of microbiota in the pathophysiology of uterine fibroids - a systematic review.Frontiers in cellular and infection microbiology · 2023Pooled it
- Association Between Vaginal Microbiota and Female Infertility: A Systematic Review and Meta-Analysis.Microorganisms · 2026Review
- Exploring emerging concepts in the pathophysiology of PCOS: microbiome dysbiosis and immunological dysregulation.Reproduction & fertility · 2026Review
- Presence and Dominance ofDiseases (Basel, Switzerland) · 2026Article
- Microbiological Profiling of Menstrual Blood Aspirated from the Uterus in Patients Undergoing Frozen Embryo Transfer.Diagnostics (Basel, Switzerland) · 2026Article
- Endometrial microbiota-dimethylglycine-Treg cell axis affects endometrial receptivity in recurrent implantation failure.Science China. Life sciences · 2026Article
- Effect of improvement in the endometrial microbiome on in vitro fertilization outcomes.Journal of assisted reproduction and genetics · 2026Article
- Vaginal bacteria-derived extracellular vesicles diffuse through human cervicovaginal mucus to enable microbe-host signaling.NPJ biofilms and microbiomes · 2026Article
- Beyond community state types: vaginal microbial diversity and CST-IV signatures are associated with pregnancy in euploid embryo transfer cycles.Frontiers in endocrinology · 2026Article
- Vaginal microbiota in assisted reproduction: determinants, dynamics, and impact on clinical outcomes.Frontiers in microbiology · 2026Review
- Implantation Failure: Where to Look Up?Journal of clinical medicine · 2025Review
- Endometrial Microbiome and Reproductive Receptivity: Diverse Perspectives.International journal of molecular sciences · 2025Review
- Article
- Comparative analysis of uterine flora in pregnant women undergoing elective and non-elective caesarean section of central Uttar Pradesh, India.Journal of family medicine and primary care · 2025Article
- Behind-the-Scenes Actors in Fertility: A Comprehensive Review of the Female Reproductive Tract Microbiome and Its Clinical Relevance.Life (Basel, Switzerland) · 2025Review
- Endometrial microbiome in reproductive failure: The possibility of metagenomic analysis.Clinical and experimental reproductive medicine · 2025Article
- Microbiome-Maternal Tract Interactions in Women with Recurrent Implantation Failure.Microorganisms · 2025Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo identify specific bacterial communities in vaginal and endometrial microbiotas as biomarkers of implantation failure by comprehensively analyzing their microbiotas using next-generation sequencing.
methodsWe investigated α- and β-diversities of vaginal and endometrial microbiotas using 16S rRNA gene sequencing and compared their profiles between 145 women with repeated implantation failure (RIF) and 21 controls who lacked the factors responsible for implantation failure with a high probability of being healthy and fertile to identify specific bacteria that induce implantation failure.
resultsThe endometrial microbiotas had higher α-diversities than did the vaginal microbiotas (
conclusionsImpaired microbiota communities containing specific bacteria in both the endometrium and vagina were associated with implantation failure. The vaginal
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.