ArticleClinical medicine insights. Arthritis and musculoskeletal disorders2021
Interstitial Lung Disease and its Associations in Rheumatoid Arthritis: Data from a District General Hospital in Sri Lanka.
Article in Clinical medicine insights. Arthritis and musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.
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Who cites it
5 citing papers in PubMed, 3 syntheses or guidelines pooled it, 3 citations in OpenAlex.
- The global prevalence of interstitial lung disease in patients with rheumatoid arthritis: a systematic review and meta-analysis.Rheumatology international · 2025Pooled it
- Patient-level factors predictive of interstitial lung disease in rheumatoid arthritis: a systematic review.RMD open · 2023Pooled it
- Factors associated with interstitial lung disease in patients with rheumatoid arthritis: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Development of a risk prediction model for rheumatoid arthritis-associated interstitial lung disease based on interpretable machine learning.Clinical rheumatology · 2026Article
- The prevalence of interstitial lung disease in rheumatoid arthritis: a systematic review.Rheumatology advances in practice · 2026Review
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1 author.
Funding
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Abstract
contextInterstitial lung disease (ILD) is a frequent pulmonary manifestation of rheumatoid arthritis (RA). No Sri Lankan studies have determined the prevalence of lung disease in RA and its associations.
aimsTo find the prevalence of ILD in RA and its association with rheumatoid factor (RF), erosions, Disease activity score in 28 joints (DAS 28), disease duration, Body mass index(BMI), erythrocyte sedimentation rate (ESR), smoking, and also to determine the prevalence of lung disease with demographic factors like age, sex, and income. SETTINGS AND
designQuestionnaire based retrospective study at a District General Hospital in Sri Lanka. MATERIALS AND
methodsDiagnosed RA patients included through convenient sampling as it was a simple method that could facilitate data collection in a short duration. Since all patients with a diagnosis of RA were eligible, all consecutive patients with a diagnosis of RA at the rheumatology clinics were included in the study. To reduce the bias a large sample of patients were used as well as patients attending different rheumatology clinics were included and also patients who were referred to the hospital from peripheries were included in the study. The calculated sample size was 384 and according to patient numbers attending clinics, a period of 6 months was decided to select the study sample. STATISTICAL ANALYSIS USED: Chi-Square calculation and logistic regression analysis using Minitab 17 software.
resultsFrom 384 patients, the prevalence of ILD was 14.58%, been 5.4% in early RA (<2 years disease duration). Mean age of ILD group was 52.94 years (95% CI 64.66-41.22). Mean RA duration was 7.69 years (95% CI, 2.38-12.99). Male to female sex ratio of RA was 1:7, and that of ILD was 2:9. DAS 28 was 4.58 (95% CI, 3.48-5.68). Statistically significant associations were noted with ILD and DAS 28 (
conclusionsILD significantly associates RA severity indices like DAS 28, ESR, erosions, RF, and also with smoking. No significant association was found with BMI or gender difference. Therefore, disease severity indices could be used to predict progression to ILD in RA.
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