ArticleNature and science of sleep2021
Excessive Daytime Sleepiness and Cardiovascular Mortality in US Adults: A NHANES 2005-2008 Follow-Up Study.
Article in Nature and science of sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Effect of Excessive Daytime Sleepiness and Long Sleep Duration on All Cause Dementia: A Systematic Review and Meta-analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Pooled it
- Fabry disease and sleep disorders: a systematic review.Frontiers in neurology · 2023Pooled it
- The effect of caffeinated beverage consumption on the relationship between sleep quality and major adverse cardiovascular events: Sleep Heart Health Study.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Hypertension and Racial/Ethnic Disparities in Sleep Outcomes among Adults in the 2011-2023 National Health and Nutrition Examination Survey.American journal of hypertension · 2026Article
- Association of cardiometabolic index and glomerular filtration rate with sleep disorders: NHANES 2005-2020.Journal of health, population, and nutrition · 2025Article
- Assessment of Comprehensive Patient-Reported Outcomes Before and After CPAP Therapy in Obstructive Sleep Apnea.Biomedicines · 2025Article
- Hypersomnolence in focus: a white paper of the 6th Think Tank World Sleep Forum.Sleep medicine · 2025Review
- What are the important risk factors for excessive daytime sleepiness in a population-based cohort?Journal of sleep research · 2025Article
- Exploring the relationship between sleep characteristics and cardiovascular biomarkers among adults aged 46-85 years measured in the Doetinchem cohort study.Scientific reports · 2025Article
- Overall Sleep Quality Is Associated With Advanced Stages in Patients With Cardiovascular-Kidney-Metabolic Syndrome.Journal of the American Heart Association · 2025Article
- Conventional and regionally distinctive risk factors for first-onset myocardial infarction: the Bangladesh Risk of Acute Vascular Events (BRAVE) case-control study.The Lancet regional health. Southeast Asia · 2025Article
- Age modulates the predictive value of self-reported sleepiness for all-cause mortality risk: insights from a comprehensive national database of veterans.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Article
- Protocol for a randomized controlled trial of moderate intensity interval training in individuals with chronic obstructive pulmonary disease and obstructive sleep apnea overlap syndrome who have excessive daytime sleepiness.Contemporary clinical trials · 2024Article
- Evaluating the impact of automatic positive airway pressure therapy on cardiovascular risk index and vascular behavior in patients with obstructive sleep apnea: a study on heterogeneity in the therapeutic response.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Beyond sleep duration: protocol for a systematic review of multidimensional sleep health in relation to cardiovascular disease and mortality.Frontiers in sleep · 2024Article
- Systemic immune-inflammation index (SII) and the risk of all-cause, cardiovascular, and cardio-cerebrovascular mortality in the general population.European journal of medical research · 2023Article
- Daytime sleepiness is associated with increased coronary plaque burden among patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2023Article
- Article
- The relationship between preserved ratio impaired spirometry and mortality in the myocardial infarction survivors: a population-based cohort study.BMC cardiovascular disorders · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeExcessive daytime sleepiness is highly prevalent and has been associated with increased risk of cardiovascular diseases, but evidence for its association with cardiovascular mortality is limited and inconsistent. We aimed to determine whether excessive daytime sleepiness is independently associated with cardiovascular mortality in general adult population. PATIENTS AND
methodsA prospective study of 10,330 adult participants (aged ≥20 years) from National Health and Nutrition Examination Survey (NHANES) 2005-2006 and 2007-2008 was followed up until December 31st, 2015. Excessive daytime sleepiness was defined as the self-reported feeling of being overly sleepy often or always during the day. Cox proportional hazard ratios (HRs) with 95% confidence interval (CI) were estimated to assess risk for cardiovascular mortality.
resultsA total of 10,330 participants with mean age of 47.3 years (95% CI, 46.0 to 48.1) were included in this analysis. Approximately, 18.5% of US adults reported excessive daytime sleepiness. Over a mean follow-up of 8.3 years, 262 cardiovascular deaths occurred. Participants with excessive daytime sleepiness had 2.85-times greater risk (95% CI, 1.33-6.09) of cardiovascular death than those without daytime sleepiness in multivariable analysis corrected for sociodemographic factors, comorbidities and cardiovascular risk factors including depression. Further adjustment for self-reported sleep disorders and sleep duration only slightly attenuated this association (HR, 2.55; 95% CI, 1.23-5.27). No interactions between excessive daytime sleepiness and age, sex or cardiovascular disease at study entry were observed (all
conclusionExcessive daytime sleepiness is highly prevalent among US adults and is independently associated with an approximately two-and-a-half-fold increased risk of cardiovascular mortality in a large national sample. Screening for excessive daytime sleepiness may be a simple and cost-effective tool for identifying individuals at high risk of cardiovascular death.
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Registered trials
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