Evidence map›Paper›PMID 34262268›Full record

ArticleClinical interventions in aging2021

Impact of Severe Sarcopenia on Rehospitalization and Survival One Year After a TAVR Procedure in Patients Aged 75 and Older.

Céline Brouessard, Anne Sophie Bobet, Marie Mathieu, Thibaut Manigold, Pierre Paul Arrigoni, Thierry Le Tourneau, Laure De Decker, Anne-Sophie Boureau

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical interventions in aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Céline BrouessardDepartment of Geriatrics, University Hospital, Nantes, France.
Anne Sophie BobetDepartment of Geriatrics, University Hospital, Nantes, France.
Marie MathieuDepartment of Geriatrics, University Hospital, Nantes, France.
Thibaut ManigoldDepartment of Cardiology, Institut du Thorax, University Hospital, Nantes, France.
Pierre Paul ArrigoniDepartment of Radiology, University Hospital, Nantes, France.
Thierry Le TourneauUniversité de Nantes, CHU Nantes, CNRS, INSERM, Institut du Thorax, Nantes, F-44000, France.
Laure De DeckerDepartment of Geriatrics, University Hospital, Nantes, France.
Anne-Sophie BoureauDepartment of Geriatrics, University Hospital, Nantes, France.
Centre Hospitalier Universitaire de Nantes · FRInstitut du Thorax · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscatheter aortic-valve replacement (TAVR) reduces mortality and improves quality of life in patients with severe aortic valve stenosis. One third of patients have no benefit one year after TAVR. Sarcopenia, an age-related loss of skeletal muscle mass, is associated with increased physical disability and mortality. The main purpose was to evaluate the impact of severe sarcopenia on rehospitalization one year after TAVR in older patients.

methodsAll patients aged ≥75 referred for a TAVR in 2018 were included. Severe sarcopenia was defined by a loss of skeletal muscle mass defined on CT-scan measurement associated with a gait speed ≤0.8m/s. The main outcome was rehospitalization one year after TAVR.

resultsMedian age of the 182 included patients was 84, and 35% had an unplanned hospitalization at one year. Severe sarcopenia was diagnosed in 9 patients (4.9%). Univariable analysis showed that gait speed was a factor associated with readmission [HR=0.32, 95% CI (0.10-0.97), p=0.04] but not severe sarcopenia. In multivariable analysis, only diabetes was significantly associated with rehospitalization [HR=2.06, 95% CI (1.11-3.84), p=0.02]. Prevalence of severe sarcopenia varied according to different thresholds of skeletal muscle mass on CT-scan.

conclusionEven though severe sarcopenia was not correlated with rehospitalization and mortality at one year after TAVR, our results emphasize the changes in the prevalence according to cutoff used. It highlights the need to define standardized methods and international threshold for sarcopenia diagnosis by CT-scan measurements, in general population and for patients with valvular heart disease.

Indexed as

Aortic Valve StenosisQuality of LifeSarcopeniaWalking SpeedAged, 80 and overFemaleHumansLong Term Adverse EffectsMaleMuscle, SkeletalPatient ReadmissionRisk AssessmentRisk FactorsSeverity of Illness IndexTomography, X-Ray ComputedTranscatheter Aortic Valve Replacementaortic stenosishospitalizationoldersarcopeniatranscatheter aortic valve replacement

Identifiers

PMID34262268
PMCPMC8274520
OpenAlexW3181800265

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.