Evidence map›Paper›PMID 34262232›Full record

ArticleComputer methods in applied mechanics and engineering2021

Parameterization, geometric modeling, and isogeometric analysis of tricuspid valves.

Emily L Johnson, Devin W Laurence, Fei Xu, Caroline E Crisp, Arshid Mir, Harold M Burkhart, Chung-Hao Lee, Ming-Chen Hsu

Open access · greenAbstract read
In one paragraph

Article in Computer methods in applied mechanics and engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  6. Coupling Models of Resistive Valves to Muscle Mechanics in Cardiac Fluid-Structure Interaction Simulations.International journal for numerical methods in biomedical engineering · 2025
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  16. The effects of leaflet material properties on the simulated function of regurgitant mitral valves.Journal of the mechanical behavior of biomedical materials · 2023
    Article
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Emily L JohnsonDepartment of Mechanical Engineering, Iowa State University, 2043 Black Engineering, Ames, Iowa 50011, USA.
Devin W LaurenceSchool of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, Oklahoma 73019, USA.
Fei XuAnsys Inc., 807 Las Cimas Parkway, Austin, Texas 78746, USA.
Caroline E CrispDepartment of Mechanical Engineering, Iowa State University, 2043 Black Engineering, Ames, Iowa 50011, USA.
Arshid MirDivision of Pediatric Cardiology, Department of Pediatrics, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
Harold M BurkhartDivision of Cardiothoracic Surgery, Department of Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
Chung-Hao LeeSchool of Aerospace and Mechanical Engineering, The University of Oklahoma, Norman, Oklahoma 73019, USA.
Ming-Chen HsuDepartment of Mechanical Engineering, Iowa State University, 2043 Black Engineering, Ames, Iowa 50011, USA.
Iowa State University · USUniversity of Oklahoma · USUniversity of Oklahoma Health Sciences Center · USAnsys (United States) · US

Funding

Biomechanical indicators of bicuspid aortic valve dysfunctionR01HL142504 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI GORMAN, ROBERT C, HSU, MING-CHEN · 2018 to 2021
$2.9M
Novel Simulation Technologies for BHV Long-Term DurabilityR01HL129077 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI HUGHES, THOMAS J., MANNING, KEEFE B · 2016 to 2019
$2.1M
American Heart Association-American Stroke Association 16SDG27760143NHLBI NIH HHS R01 HL129077NHLBI NIH HHS R01 HL142504
6 · The paper itself

Abstract

Approximately 1.6 million patients in the United States are affected by tricuspid valve regurgitation, which occurs when the tricuspid valve does not close properly to prevent backward blood flow into the right atrium. Despite its critical role in proper cardiac function, the tricuspid valve has received limited research attention compared to the mitral and aortic valves on the left side of the heart. As a result, proper valvular function and the pathologies that may cause dysfunction remain poorly understood. To promote further investigations of the biomechanical behavior and response of the tricuspid valve, this work establishes a parameter-based approach that provides a template for tricuspid valve modeling and simulation. The proposed tricuspid valve parameterization presents a comprehensive description of the leaflets and the complex chordae tendineae for capturing the typical three-cusp structural deformation observed from medical data. This simulation framework develops a practical procedure for modeling tricuspid valves and offers a robust, flexible approach to analyze the performance and effectiveness of various valve configurations using isogeometric analysis. The proposed methods also establish a baseline to examine the tricuspid valve's structural deformation, perform future investigations of native valve configurations under healthy and disease conditions, and optimize prosthetic valve designs.

Indexed as

atrioventricular valvesisogeometric analysisparametric modelingtemplate-based approachtricuspid valvesvalvular heart disease

Identifiers

PMID34262232
PMCPMC8274564
OpenAlexW3173916631

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.