ArticleNature2021
Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 212 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
212citing papers in PubMed, 1 pooled it
21.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
212 citing papers in PubMed, 1 synthesis or guideline pooled it, 314 citations in OpenAlex.
- Comparative efficacy of cognitive training modalities in cognitive impairment: A systematic review and network meta-analysis.The journal of prevention of Alzheimer's disease · 2025Pooled it
- Article
- Article
- Neurodegenerative diseases and immune system: From pathogenic mechanism to therapy.Neural regeneration research · 2026Article
- Microglia-mediated synaptic pruning in neural circuit remodeling: multidimensional control in homeostasis and neuropathology.BMC medicine · 2026Review
- Astrocyte-to-microglia purinergic signaling mediates synaptic shielding and promotes neuronal activity.bioRxiv : the preprint server for biology · 2026Article
- Microglial checkpoint collapse in Alzheimer's disease: a tri-axial framework for biomarker-informed neuroimmune therapy.Journal of neuroinflammation · 2026Review
- Review
- Role Shift of Glial Cells from Physiology to Pathology in Alzheimer's Disease: The Regulatory Impact of Exercise.Neuroscience bulletin · 2026Review
- Astrocytic Redox Homeostasis as a Metabolic Modulator of DNA Damage and Repair in the Ischemic Penumbra.Cells · 2026Review
- Astrocyte-driven multicellular mechanisms of CNS repair and cerebroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Glial Cells in Behavioral and Psychological Symptoms of Alzheimer's Disease.International journal of molecular sciences · 2026Review
- Article
- IL-3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer's disease pathology.Nature aging · 2026Article
- Context-Dependent Regulation of Microglial Metabolic and Immune States via IL-3/CD123 Signaling: Implications for Glial Crosstalk and Cognitive Impairment.Molecular neurobiology · 2026Review
- Hippo-YAP/TAZ Signaling in Astrocytes and Microglia: Role in Neuroinflammation, Neurodegeneration and Glial Tumors.International journal of molecular sciences · 2026Review
- Scalable discovery of spatial multicellular patterns via neighborhood-to-sequence transformation.Communications biology · 2026Article
- Oligodendrocyte precursor cells-microglia crosstalk via BMP4 drives microglial neuroprotective response and mitigates Alzheimer's disease.Signal transduction and targeted therapy · 2026Article
- Fibrosis-memory is mediated by IL-3-producing T cells and drives progression of fibrosis.The Journal of clinical investigation · 2026Article
152 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
27 authors at 4 institutions in 2 countries.
Cameron S McAlpineCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Joseph ParkGenetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Ana GriciucGenetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Eunhee KimGenetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Se Hoon ChoiGenetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Yoshiko IwamotoCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Máté G KissCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9215-8328
Kathleen A ChristieCenter for Genomic Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Claudio VinegoniCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9818-3639
Wolfram C PollerCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
John E MindurCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2212-3904
Christopher T ChanCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Shun HeCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Henrike JanssenCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Lai Ping WongDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Jeffrey DowneyCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Sumnima SinghCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Atsushi AnzaiCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7474-1309
Florian KahlesCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Mehdi JorfiGenetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.ORCID http://orcid.org/0000-0003-4724-6190
Paolo Fumene FeruglioDepartment of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Ruslan I SadreyevDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Ralph WeisslederCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0828-4143
Benjamin P KleinstiverCenter for Genomic Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5469-0655
Matthias NahrendorfCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4021-1887
Rudolph E TanziGenetics and Aging Research Unit, McCance Center for Brain Health, Mass General Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA. rtanzi@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-7032-1454
Filip K SwirskiCenter for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. filip.swirski@mssm.edu.ORCID http://orcid.org/0000-0002-3163-9152
Harvard University · USMassachusetts General Hospital · USAllen Institute for Brain Science · USUniversity of Verona · IT
Funding
Translational imaging and nanomedicine in inflammatory atherosclerosisP01HL131478 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Filip K Swirski · 2017 to 2026
$24.3MPROJECT 4: Somatic evolution of the hematopoietic system in cardiovascular diseaseP01HL142494 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Matthias Nahrendorf · 2019 to 2026
$19.5MImaging organ system interfaces in ischemic heart diseaseR35HL139598 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS · 2018 to 2024
$6.9MMacrophages in homeostasis and cardiovascular diseaseR35HL135752 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SWIRSKI, FILIP K · 2017 to 2023
$5.4MInfluence of sleep on the hematopoietic niche and atherosclerosis during agingR01HL158534 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MCALPINE, CAMERON STUART · 2021 to 2025
$2.1MUNDERSTANDING AND LEVERAGING MOLECULAR DIVERSITY WITHIN THE PHYTOCHROME SUPERFAMILYR35GM139598 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LAGARIAS, JOHN CLARK · 2021 to 2025
$2.0MTargeting the JAK/STAT-3 Pathway Signaling Axis in GliomaR01CA158534 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BENVENISTE, ETTY N · 2012 to 2016
$1.5MInfluence of sleep on hematopoietic stem cell diversity and clonality in cardiovascular diseaseR00HL151750 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MCALPINE, CAMERON STUART · 2021 to 2023
$747kOptimizing Cancer Immunotherapy Safety and Efficacy using Genome EditingR00CA218870 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KLEINSTIVER, BENJAMIN PETER · 2018 to 2020
$730kInfluence of sleep on hematopoietic stem cell diversity and clonality in cardiovascular diseaseK99HL151750 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MCALPINE, CAMERON STUART · 2020 to 2020
$171kRole of interleukin-3 in autoimmune and viral myocarditisF31HL147364 · NHLBI · HARVARD MEDICAL SCHOOL · PI MINDUR, JOHN EDWARD · 2019 to 2021
$83kFASEB Summer Conference on Protein PhosphatasesR13CA135752 · NCI · FEDERATION OF AMER SOC FOR EXPER BIOLOGY · PI BENNETT, ANTON M · 2008 to 2012
$16kNCI NIH HHS R00 CA218870NCI NIH HHS R01 CA158534NCI NIH HHS R13 CA135752NHLBI NIH HHS F31 HL147364NHLBI NIH HHS K99 HL151750NHLBI NIH HHS P01 HL131478NHLBI NIH HHS P01 HL142494NHLBI NIH HHS R00 HL151750NHLBI NIH HHS R01 HL158534NHLBI NIH HHS R35 HL135752NHLBI NIH HHS R35 HL139598NIGMS NIH HHS R35 GM139598
Abstract
Communication within the glial cell ecosystem is essential for neuronal and brain health
Indexed as
Alzheimer DiseaseAnimalsAstrocytesCell CommunicationCells, CulturedHumansInterleukin-3MiceMice, Inbred C57BLMice, KnockoutMicrogliaNeural Stem CellsIL3 protein, humanInterleukin-3
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.