ArticleNature2021
Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
What it found
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Who cites it
64 citing papers in PubMed, 144 citations in OpenAlex.
- Substrate Binding Relieves Autoinhibition of the Mammalian GCN2 Kinase.bioRxiv : the preprint server for biology · 2026Article
- Arrestins as programmable integrators of GPCR signaling: structural microstates, spatiotemporal logic, and therapeutic control.Cell discovery · 2026Review
- The Origins of GPCRs.International journal of molecular sciences · 2026Review
- Elevated conformational dynamics makes ACKR3 activation-prone and G protein-incompetent.bioRxiv : the preprint server for biology · 2026Article
- A structural overview of G-protein-coupled receptors in neurological disorders.Acta pharmacologica Sinica · 2026Review
- Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway.Nature structural & molecular biology · 2026Article
- Cooperative Control of Arrestin Activation By Membrane Lipids And Phosphorylation Barcodes.bioRxiv : the preprint server for biology · 2026Article
- Revealing GRK5 Activation Features by Interpretable Machine Learning and Molecular Dynamics Simulation.International journal of molecular sciences · 2026Article
- Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy.Nature communications · 2026Article
- Regulation of G protein-coupled receptor kinase 2 and its role in tumors.Journal of translational medicine · 2026Review
- Strategic advances for cryo-EM structural studies of small (<100 kDa) GPCRs.Communications biology · 2026Review
- Distinct membrane binding properties of the two non-visual arrestins.Communications biology · 2026Article
- Elucidating biased signaling in class A GPCRs.Trends in pharmacological sciences · 2025Review
- Conformational Heterogeneity Underlying Divergent Signaling in Class A G Protein-Coupled Receptors.ACS pharmacology & translational science · 2025Review
- Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy.bioRxiv : the preprint server for biology · 2025Article
- Advancements and future directions in Oguchi disease research.International ophthalmology · 2025Review
- Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation.Nature communications · 2025Article
- GPCR kinases phosphorylate GPCR C-terminal peptides in a hierarchical manner.Communications biology · 2025Article
- Artificial Intelligence: A New Tool for Structure-Based G Protein-Coupled Receptor Drug Discovery.Biomolecules · 2025Review
- How Ligands Achieve Biased Signaling toward Arrestins.Biochemistry · 2025Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Qiuyan ChenDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Manolo PlasenciaDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.
Zhuang LiDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0002-7249-9029
Somnath MukherjeeDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5447-4496
Dhabaleswar PatraDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0001-6520-6972
Chun-Liang ChenDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0003-4625-4340
Thomas KloseDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0002-2150-9792
Xin-Qiu YaoDepartment of Chemistry, Georgia State University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-2706-2028
Anthony A KossiakoffDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Leifu ChangDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0002-6107-5271
Philip C AndrewsDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.
John J G TesmerDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA. jtesmer@purdue.edu.ORCID http://orcid.org/0000-0003-1125-3727
Purdue University West Lafayette · USUniversity of Chicago · USUniversity of Michigan · USGeorgia State University · US
Funding
Structure, function, and inhibition of G protein-coupled receptor kinasesR01HL071818 · NHLBI · UNIVERSITY OF TEXAS AUSTIN · PI TESMER, JOHN · 2004 to 2023
$7.1MNext-generation Mass Spectrometry Technologies for Integrated Structural Proteomics- RenewalR01GM095832 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUOTOLO, BRANDON T · 2011 to 2024
$5.8MChaperone-Assisted Structure Determination of Membrane ProteinsR01GM117372 · NIGMS · UNIVERSITY OF CHICAGO · PI ANTHONY A KOSSIAKOFF · 2016 to 2026
$4.0MRegulation of the metastasis promoting chemokine receptor ACKR3 by GPCR kinases, Gβγ and arrestinsR01CA254402 · NCI · PURDUE UNIVERSITY · PI HANDEL, TRACY M, TESMER, JOHN · 2020 to 2024
$3.2MStructure and Function of the LPLA2/LCAT Acyltransferase FamilyR01HL122416 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TESMER, JOHN · 2015 to 2018
$1.9MGOLGI MATRIX ASSEMBLY AND DISASSEMBLY IN THE CELL CYCLER01GM105920 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREWS, PHILIP C, WANG, YANZHUANG · 2014 to 2017
$1.9MGPCR - Linked RhoGEFs in Tumor Growth and MetastasisR01CA221289 · NCI · PURDUE UNIVERSITY · PI TESMER, JOHN · 2018 to 2022
$1.9MNew Structural Mass Spectrometry Tools Applied to the Mitochondrial Membrane ProtR01GM105942 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREWS, PHILIP C, RUOTOLO, BRANDON T · 2013 to 2016
$1.4MExploration of Molecular Chaperone Complexes During Active Protein TriageR01GM109896 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDREWS, PHILIP C, GESTWICKI, JASON E · 2014 to 2017
$1.1MNCI NIH HHS R01 CA221289NCI NIH HHS R01 CA254402NHLBI NIH HHS R01 HL071818NHLBI NIH HHS R01 HL122416NIGMS NIH HHS R01 GM095832NIGMS NIH HHS R01 GM105920NIGMS NIH HHS R01 GM105942NIGMS NIH HHS R01 GM109896NIGMS NIH HHS R01 GM117372
Abstract
G-protein-coupled receptor (GPCR) kinases (GRKs) selectively phosphorylate activated GPCRs, thereby priming them for desensitization
Indexed as
Amino Acid SequenceAnimalsBinding SitesCattleCryoelectron MicroscopyG-Protein-Coupled Receptor Kinase 1Protein Structure, TertiaryRhodopsinSignal TransductionG-Protein-Coupled Receptor Kinase 1Rhodopsin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.