ArticleHeredity2021
A major quantitative trait locus affecting resistance to Tilapia lake virus in farmed Nile tilapia (Oreochromis niloticus).
Article in Heredity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- Screening and Application of Novel DNA Aptamers for Targeting Tilapia Lake Virus-Infected Cells.Journal of fish diseases · 2026Article
- Fine mapping and functional annotation of a QTL for resistance to tilapia lake virus in Nile tilapia (Oreochromis niloticus).G3 (Bethesda, Md.) · 2026Article
- First development of a 100 K SNP array for small yellow croaker and its application in genomic selection for growth and disease resistance.BMC genomics · 2025Article
- Skin and gill microbiome profiles and network structures in farmed tilapia (Oreochromis niloticus) and their relationships with health conditions.Animal microbiome · 2025Article
- Selection for Growth Performance inAnimals : an open access journal from MDPI · 2025Article
- Reconstruction of the X and Y haplotypes in the genetically improved Abbassa nile tilapia genome assembly.Scientific reports · 2025Article
- Zoonotic Agents in Farmed Fish: A Systematic Review from the Interdisciplinary Perspective of the One Health Concept.Veterinary sciences · 2025Review
- The ecology and plasticity of fish skin and gill microbiomes: seeking what matters in health and disease.FEMS microbiology reviews · 2025Review
- Genome-wide association study and transcriptomic analysis reveal the crucial role ofFrontiers in immunology · 2025Article
- Genome-Wide Association Study of Resistance to Largemouth Bass Ranavirus (LMBV) inInternational journal of molecular sciences · 2024Article
- Strong selection signatures for Aleutian disease tolerance acting on novel candidate genes linked to immune and cellular responses in American mink (Neogale vison).Scientific reports · 2024Article
- First insight of the genome-wide association study and genomic prediction into enteritis disease (Frontiers in immunology · 2024Article
- Applying genetic technologies to combat infectious diseases in aquaculture.Reviews in aquaculture · 2023Review
- Immune responses to Tilapia lake virus infection: what we know and what we don't know.Frontiers in immunology · 2023Review
- GWAS on Imputed Whole-Genome Sequence Variants Reveal Genes Associated with Resistance toGenes · 2022Article
- Chromosome-level genome sequence of the Genetically Improved Farmed Tilapia (GIFT, Oreochromis niloticus) highlights regions of introgression with O. mossambicus.BMC genomics · 2022Article
- Animal board invited review: Widespread adoption of genetic technologies is key to sustainable expansion of global aquaculture.Animal : an international journal of animal bioscience · 2022Review
- First identification of two co-existing genome-wide significant sex quantitative trait loci (QTL) in red tilapia using integrative QTL mapping.Zoological research · 2022Article
- Genomic Selection and Genome-wide Association Study for Feed-Efficiency Traits in a Farmed Nile Tilapia (Frontiers in genetics · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Enhancing host resistance to infectious disease has received increasing attention in recent years as a major goal of farm animal breeding programs. Combining field data with genomic tools can provide opportunities to understand the genetic architecture of disease resistance, leading to new opportunities for disease control. In the current study, a genome-wide association study was performed to assess resistance to the Tilapia lake virus (TiLV), one of the biggest threats affecting Nile tilapia (Oreochromis niloticus); a key aquaculture species globally. A pond outbreak of TiLV in a pedigreed population of the GIFT strain was observed, with 950 fish classified as either survivor or mortality, and genotyped using a 65 K SNP array. A significant QTL of large effect was identified on chromosome Oni22. The average mortality rate of tilapia homozygous for the resistance allele at the most significant SNP (P value = 4.51E-10) was 11%, compared to 43% for tilapia homozygous for the susceptibility allele. Several candidate genes related to host response to viral infection were identified within this QTL, including lgals17, vps52, and trim29. These results provide a rare example of a major QTL affecting a trait of major importance to a farmed animal. Genetic markers from the QTL region have potential in marker-assisted selection to improve host resistance, providing a genetic solution to an infectious disease where few other control or mitigation options currently exist.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.