ArticleScientific reports2021
GIP_HUMAN[22-51] is a new proatherogenic peptide identified by native plasma peptidomics.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 8 citations in OpenAlex.
- Preparation of the Low Molecular Weight Serum Proteome for Mass Spectrometry Analysis.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Integrating a Multi-label Deep Learning Approach with Protein Information to Compare Bioactive Peptides in Brain and Plasma.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- ANGT_HUMAN[448-462], an Anorexigenic Peptide Identified Using Plasma Peptidomics.Journal of the Endocrine Society · 2022Article
- The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection.Frontiers in endocrinology · 2022Article
- LC-MS peak assignment based on unanimous selection by six machine learning algorithms.Scientific reports · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
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Abstract
We recently established a new plasma peptidomic technique and comprehensively identified a large number of low-molecular weight and low-abundance native peptides using a single drop of human plasma. To discover a novel polypeptide that potently modulates the cardiovascular system, we performed a bioinformatics analysis of the large-scale identification results, sequentially synthesized the selected peptide sequences, tested their biological activities, and identified a 30-amino-acid proatherogenic peptide, GIP_HUMAN[22-51], as a potent proatherosclerotic peptide hormone. GIP_HUMAN[22-51] has a common precursor with the glucose-dependent insulinotropic polypeptide (GIP) and is located immediately N-terminal to GIP. Chronic infusion of GIP_HUMAN[22-51] into ApoE
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