ArticleLight, science & applications2021
1700 nm optical coherence microscopy enables minimally invasive, label-free, in vivo optical biopsy deep in the mouse brain.
Article in Light, science & applications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Broadband 2-µm fiber-laser supercontinuum for high-resolution optical coherence tomography.Biomedical optics express · 2026Article
- Scattering-enabled epi-quantitative phase imaging reveals subcellular detail in organoids and deep mouse brains.bioRxiv : the preprint server for biology · 2026Article
- Article
- Surpassing the diffraction limit for improved lateral resolution in adaptive optics optical coherence tomography of the living human eye.Communications engineering · 2025Article
- Minimally-invasive common-path OCT system for neurosurgery applications.Biomedical optics express · 2025Article
- General Post-Regulation Strategy of AIEgens' Photophysical Properties for Intravital Two-Photon Fluorescence Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Computational approach for correcting defocus and suppressing speckle noise in line-field optical coherence tomography images.Biomedical optics express · 2024Article
- Multiple scattering suppression forBiomedical optics express · 2024Article
- Quantum optical tomography based on time-resolved and mode-selective single-photon detection by femtosecond up-conversion.Scientific reports · 2023Article
- Correcting spatial-spectral crosstalk and chromatic aberrations in broadband line-scan spectral-domain OCT images.Biomedical optics express · 2023Article
- Deep Imaging to Dissect Microvascular Contributions to White Matter Degeneration in Rodent Models of Dementia.Stroke · 2023Review
- Computational conjugate adaptive optics microscopy for longitudinal through-skull imaging of cortical myelin.Nature communications · 2023Article
- Tracking the binding of multi-functional fluorescent tags for Alzheimer's disease using quantitative multiphoton microscopy.Journal of biophotonics · 2022Article
- Intravital 3D visualization and segmentation of murine neural networks at micron resolution.Scientific reports · 2022Article
- Shedding light on biology and healthcare-preface to the special issue on Biomedical Optics.Light, science & applications · 2022Article
- Spectroscopic thermo-elastic optical coherence tomography for tissue characterization.Biomedical optics express · 2022Article
- TRPV4 mRNA is elevated in the caudate nucleus with NPH but not in Alzheimer's disease.Frontiers in genetics · 2022Article
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
- 1700 nm broadband laser source enables deep brain optical biopsy.Light, science & applications · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
In vivo, minimally invasive microscopy in deep cortical and sub-cortical regions of the mouse brain has been challenging. To address this challenge, we present an in vivo high numerical aperture optical coherence microscopy (OCM) approach that fully utilizes the water absorption window around 1700 nm, where ballistic attenuation in the brain is minimized. Key issues, including detector noise, excess light source noise, chromatic dispersion, and the resolution-speckle tradeoff, are analyzed and optimized. Imaging through a thinned-skull preparation that preserves intracranial space, we present volumetric imaging of cytoarchitecture and myeloarchitecture across the entire depth of the mouse neocortex, and some sub-cortical regions. In an Alzheimer's disease model, we report that findings in superficial and deep cortical layers diverge, highlighting the importance of deep optical biopsy. Compared to other microscopic techniques, our 1700 nm OCM approach achieves a unique combination of intrinsic contrast, minimal invasiveness, and high resolution for deep brain imaging.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.