Evidence map›Paper›PMID 34261823›Full record

ArticleIndustrial health2021

Cerebral excitability in pup rats prenatally exposed to 1-bromopropane is suppressed by bromide accumulated in the brain.

Yukiko Fueta, Mitsuo Hinoue, Hazuki Noguchi, Mizuki Matsuno, Toru Ishidao, C Edwin Garner, Hajime Hori

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Industrial health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yukiko FuetaDepartment of Environmental Management and Control, School of Health Sciences, University of Occupational and Environmental Health, Japan.
Mitsuo HinoueDepartment of Environmental Management and Control, School of Health Sciences, University of Occupational and Environmental Health, Japan.
Hazuki NoguchiDepartment of Environmental Management and Control, School of Health Sciences, University of Occupational and Environmental Health, Japan.
Mizuki MatsunoDepartment of Environmental Management and Control, School of Health Sciences, University of Occupational and Environmental Health, Japan.
Toru IshidaoDepartment of Environmental Management and Control, School of Health Sciences, University of Occupational and Environmental Health, Japan.
C Edwin GarnerPharmaceutical Development, Radikal Therapeutics, Inc., USA.
Hajime HoriDepartment of Environmental Management and Control, School of Health Sciences, University of Occupational and Environmental Health, Japan.
University of Occupational and Environmental Health Japan · JPRadikal Therapeutics · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously, we reported that prenatal exposure to 1-bromopropane (1-BP) causes the accumulation of bromide (Br-) in the brain of rat pups. Here, we aimed to investigate the effects of Br- accumulation in rat pups prenatally exposed to 1-BP vapor. Dam rats were exposed to 1-BP (400 or 700 ppm; 1-BP group) by inhalation, or to NaBr (20 mM; Br- group) in drinking water during gestation days 1-20. We also analyzed pentylenetetrazole (PTZ, 60 mg/kg, ip)-induced behavioral changes in pups prenatally exposed to 1-BP or Br- on postnatal day (PND) 14. PTZ-induced epileptic convulsions were inhibited in both 1-BP (700 ppm) and Br- groups. The inhibition of neuronal excitability induced by Br- was evaluated electrophysiologically using the hippocampal slices obtained from PND14-16 pups. PTZ (2 mM) failed to induce epileptiform discharge in the presence of 1.2 mM Br- in the slices obtained from the control group. However, it induced epileptiform discharge following the removal of Br-, by perfusing artificial cerebrospinal fluid into the slices obtained from the Br- group. Our results indicate that Br- accumulates in the brain of neonatal rat pups prenatally exposed to 1-BP vapor suppressed neuronal excitability.

Indexed as

BromidesPrenatal Exposure Delayed EffectsAnimalsBrainFemaleHydrocarbons, BrominatedPregnancyRatsRats, Wistar1-bromopropaneBromidesHydrocarbons, Brominated1-bromopropaneBromideHippocampal sliceNeurotoxicityPentylenetetrazolePrenatal exposure

Identifiers

PMID34261823
PMCPMC8426544
OpenAlexW3178947316

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.