Evidence map›Paper›PMID 34261791›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Mapping partner drug resistance to guide antimalarial combination therapy policies in sub-Saharan Africa.

Hanna Y Ehrlich, Amy K Bei, Daniel M Weinberger, Joshua L Warren, Sunil Parikh

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Malaria.The New England journal of medicine · 2025
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hanna Y EhrlichDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT 06510; hanna.ehrlich@yale.edu.ORCID 0000-0002-7501-6424
Amy K BeiDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT 06510.ORCID 0000-0003-1159-760X
Daniel M WeinbergerDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT 06510.
Joshua L WarrenPublic Health Modeling Unit, Yale School of Public Health, Yale University, New Haven, CT 06510.ORCID 0000-0002-6274-6970
Sunil ParikhDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT 06510.ORCID 0000-0001-9411-5180
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Modeling the impact and cost-effectiveness of next-generation rotavirus vaccine strategies in low- and middle-income countriesR01AI112970 · NIAID · YALE UNIVERSITY · PI PITZER, VIRGINIA E · 2015 to 2024
$4.1M
Predicting and monitoring variations in the effects of vaccines against RSVR01AI137093 · NIAID · YALE UNIVERSITY · PI Virginia E Pitzer, Daniel Martin Weinberger · 2018 to 2026
$3.4M
Employing genetic and genomic surveillance to reveal mechanisms of malaria parasite persistenceK01TW010496 · FIC · YALE UNIVERSITY · PI BEI, AMY KRISTINE · 2016 to 2021
$754k
TRANSMIT: Tracking Antimalarial Resistance in Mosquito PopulationsR21AI135477 · NIAID · YALE UNIVERSITY · PI PARIKH, SUNIL · 2018 to 2019
$450k
Optimizing spatial sampling strategies for the molecular surveillance of drug resistant malariaF31AI150168 · NIAID · YALE UNIVERSITY · PI EHRLICH, HANNA · 2020 to 2022
$87k
FIC NIH HHS K01 TW010496NCATS NIH HHS UL1 TR001863NIAID NIH HHS F31 AI150168NIAID NIH HHS R01 AI112970NIAID NIH HHS R01 AI137093NIAID NIH HHS R21 AI135477
6 · The paper itself

Abstract

Resistance to artemisinin-based combination therapies (ACTs) threatens the global control of

Indexed as

Drug ResistanceAfrica South of the SaharaAntimalarialsArtemisininsATP-Binding Cassette, Sub-Family C ProteinsBayes TheoremGenotypeHumansMalaria, FalciparumMembrane Transport ProteinsMutationPlasmodium falciparumProtozoan ProteinsAntimalarialsartemisininArtemisininsATP-Binding Cassette, Sub-Family C ProteinsMembrane Transport ProteinsProtozoan Proteinsdrug resistancemalariasurveillance

Identifiers

PMID34261791
PMCPMC8307356
OpenAlexW3181936668

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.