ArticleNeurology2021
Association of Epilepsy Surgery With Changes in Imaging-Defined Brain Age.
Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Explainable brain age prediction: a comparative evaluation of morphometric and deep learning pipelines.Brain informatics · 2024Article
- Age-related behavioral resilience in smartphone touchscreen interaction dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Geroscience-Centric Perspective for Geriatric Psychiatry: Integrating Aging Biology With Geriatric Mental Health Research.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Review
- Dynamic evolution of brain structural patterns in liver transplantation recipients: a longitudinal study based on 3D convolutional neuronal network model.European radiology · 2023Article
- Comparison of Machine Learning Models for Brain Age Prediction Using Six Imaging Modalities on Middle-Aged and Older Adults.Sensors (Basel, Switzerland) · 2023Article
- Advanced Brain Age and Chronic Poststroke Aphasia Severity.Neurology · 2023Article
- Neuroimaging-Based Brain Age Estimation: A Promising Personalized Biomarker in Neuropsychiatry.Journal of personalized medicine · 2022Review
- Regional rather than global brain age mediates cognitive function in cerebral small vessel disease.Brain communications · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveTo determine whether surgery in patients with mesial temporal lobe epilepsy (mTLE) is associated with reduced brain-predicted age as a neural marker overall brain health, we compared brain-predicted and chronologic age difference (brain age gap estimation [BrainAGE]) in patients before and after surgery with healthy controls.
methodsWe acquired 3D T1-weighted MRI scans for 48 patients with mTLE before and after temporal lobe surgery to estimate brain age using a gaussian processes regression model. We examined BrainAGE before and after surgery controlling for brain volume change, comparing patients to 37 age- and sex-matched controls.
resultsPreoperatively, patients showed an increased BrainAGE of more than 7 years compared to controls. However, surgery was associated with a mean BrainAGE reduction of 5 years irrespective of whether or not surgery resulted in complete seizure freedom. We observed a lateralization effect as patients with left mTLE had BrainAGE values that more closely resembled control group values following surgery.
conclusionsOur findings suggest that while morphologic brain alterations linked to accelerated aging have been observed in mTLE, surgery may be associated with changes that reverse such alterations in some patients. This work highlights the advantages of resective surgery on overall brain health in patients with refractory focal epilepsy.
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Registered trials
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