Evidence map›Paper›PMID 34261777›Full record

Observational studyOpen heart2021

Is percutaneous coronary intervention safe during uninterrupted direct oral anticoagulant therapy in patients with atrial fibrillation and acute coronary syndromes?

Leonardo De Luca, Andrea Rubboli, Leonardo Bolognese, Massimo Uguccioni, Donata Lucci, Simonetta Blengino, Jeness Campodonico, Ilaria Meynet, Silvia Maria Brach Prever, Andrea Di Lenarda and 3 more

Open access · goldAbstract readComparative StudyMulticenter StudyObservational Study
In one paragraph

Observational study in Open heart, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Impact of Uninterrupted Versus Interrupted Oral Anticoagulation on 30-Day Outcomes Following Coronary Angiography.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Article
  3. Article
  4. Article
  5. ANMCO-SIMEU consensus document: appropriate management of atrial fibrillation in the emergency department.European heart journal supplements : journal of the European Society of Cardiology · 2023
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Leonardo De LucaDepartment of Cardiosciences, San Camillo-Forlanini Hospital, Roma, Italy leo.deluca@libero.it.ORCID 0000-0002-8552-1272
Andrea RubboliDepartment of Cardiology, Ospedale Santa Maria delle Croci, Ravenna, Italy.
Leonardo BologneseDepartment of Cardiology, San Donato Hospital, Arezzo, Italy.
Massimo UguccioniDepartment of Cardiosciences, San Camillo-Forlanini Hospital, Roma, Italy.
Donata LucciCentro Studi ANMCO, Firenze, Italy.
Simonetta BlenginoDepartment of Cardiology, San Luca Institute Italian Institute for Auxology, Milano, Italy.
Jeness CampodonicoDepartment of Cardiology, Monzino Cardiology Centre, Milano, Italy.
Ilaria MeynetDepartment of Cardiology, Ospedale degli Infermi, Rivoli, Italy.
Silvia Maria Brach PreverDepartment of Cardiology, Ospedale San Giovanni Bosco, Torino, Italy.
Andrea Di LenardaAzienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy.
Domenico GabrielliDepartment of Cardiosciences, San Camillo-Forlanini Hospital, Roma, Italy.
Michele Massimo GuliziaDeparment of Cardiology, National Centre of Excellence Garibaldi Hospital Garibaldi-Nesima Hospital, Catania, Italy.
MATADOR-PCI Investigators
Associazione Nazionale Medici Cardiologi Ospedalieri · ITAzienda Sanitaria Universitaria Integrata di Trieste · ITCentro Cardiologico Monzino · ITIRCCS Istituto Auxologico Italiano · ITOspedale degli Infermi · ITOspedale Garibaldi · ITOspedale San Donato · ITOspedale San Giovanni Bosco · ITOspedale Santa Maria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesNo data on optimal management of patients with acute coronary syndromes (ACS) on long-term direct oral anticoagulants (DOACs) undergoing percutaneous coronary intervention (PCI) are available. Using the data of the Management of Antithrombotic TherApy in Patients with Chronic or DevelOping AtRial Fibrillation During Hospitalization for PCI study, we sought to compare the outcome of patients with ACS and atrial fibrillation (AF) who underwent PCI during uninterrupted DOAC (UDOAC group) and those who interrupted DOAC before PCI (IDOAC group).

methodsThe primary outcomes of our analysis were the incidence of major adverse cardiovascular events (MACEs), a composite of death, cerebrovascular events, recurrent myocardial infarction or revascularisation and net adverse clinical events (NACEs), including major bleeding, at 6 months.

resultsAmong the 132 patients on long-term DOAC, 72 (54.6%) underwent PCI during UDOAC and 60 (45.4%) after IDOAC. The mean CHA

conclusionsOur study shows that PCI is a safe procedure during UDOAC in patients with concomitant ACS and AF.

Indexed as

Drug-Eluting StentsRegistriesAcute Coronary SyndromeAdministration, OralAgedAnticoagulantsAtrial FibrillationFemaleFollow-Up StudiesHumansIncidenceItalyMalePercutaneous Coronary InterventionPostoperative ComplicationsProspective StudiesAnticoagulantsacute coronary syndromeatrial fibrillationepidemiologypercutaneous coronary intervention

Identifiers

PMID34261777
PMCPMC8281094
OpenAlexW3182965076

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.