Evidence map›Paper›PMID 34261677›Full record

SynthesisBMJ open2021

Respiratory-associated deaths in people with intellectual disabilities: a systematic review and meta-analysis.

Maria Truesdale, Craig Melville, Fiona Barlow, Kirsty Dunn, Angela Henderson, Laura Anne Hughes-McCormack, Arlene McGarty, Ewelina Rydzewska, Gillian S Smith, Joseph Symonds and 2 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Community-Sourced Reporting of Mortalities in Angelman Syndrome (1979-2022).American journal of medical genetics. Part A · 2025
    Article
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Maria TruesdaleInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK Maria.truesdale@glasgow.ac.uk.ORCID 0000-0003-3081-7858
Craig MelvilleInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Fiona BarlowInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Kirsty DunnInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Angela HendersonInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.ORCID 0000-0002-6146-3477
Laura Anne Hughes-McCormackInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.ORCID 0000-0001-9498-8045
Arlene McGartyInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Ewelina RydzewskaInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Gillian S SmithInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.ORCID 0000-0001-7241-6951
Joseph SymondsInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Bhautesh JaniInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Deborah KinnearInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
University of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo review and synthesise evidence on rates of respiratory-associated deaths and associated risk factors in the intellectual disability population.

designSystematic review and meta-analysis. DATA SOURCES: Embase, CINAHL, ISI Web of Science (all databases including Medline) and PsychINFO were searched for studies published between 1st January 1985 and 27th April 2020 and examined study and outcome quality. Reference lists and Google Scholar were also hand searched.

resultsWe identified 2295 studies, 17 were included in the narrative synthesis and 10 studies (11 cohorts) in the meta-analysis. Data from 90 302 people with intellectual disabilities and 13 808 deaths from all causes in people with intellectual disabilities were extracted. Significantly higher rates of respiratory-associated deaths were found among people with intellectual disabilities (standardised mortality ratio(SMR): 10.86 (95% CI: 5.32 to 22.18, p<0.001) compared with those in the general population, lesser rates for adults with ID (SMR: 6.53 (95% CI: 4.29 to 9.96, p<0.001); and relatively high rates from pneumonia 26.65 (95% CI: 5.63 to 126.24, p<0.001). The overall statistical heterogeneity was I

conclusionPremature deaths due to respiratory disorders are potentially avoidable with improved public health initiatives and equitable access to quality healthcare. Further research should focus on developing prognostic guidance and validated tools for clinical practice to mitigate risks of respiratory-associated deaths. PROSPERO REGISTRATION NUMBER: CRD42020180479.

Indexed as

Intellectual DisabilityRespiration DisordersAdultCause of DeathHumansMortality, PrematureRisk Factorspublic healthrespiratory infectionsrespiratory medicine (see thoracic medicine)

Identifiers

PMID34261677
PMCPMC8280912
OpenAlexW3160116437

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.