ArticleScience advances2021
Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia.
Open access · goldAbstract read
In one paragraph
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 4% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Meta-analysis across six global biobanks identifies recessive coding associations with complex traits and diseases.American journal of human genetics · 2026Pooled it
- Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.Nature communications · 2025Pooled it
- Changes in hemoglobin levels and cardiometabolic health in adults with metabolic syndrome - a secondary outcome analysis of a six-month randomized controlled trial.Annals of medicine · 2026Trial
- Review
- Associations of hemoglobin levels with structural knee MRI findings at 33 years of age in a general population-based birth cohort.Osteoarthritis and cartilage open · 2026Article
- Carbon monoxide-releasing molecule CORM-401 treatment elicits corticosterone-driven stress lipolysis and tissue-specific hypoxia-inducible factor activation.Redox biology · 2026Article
- U-shaped association between hemoglobin levels and cardiometabolic multimorbidity in older adults: a large-scale cross-sectional study.BMC geriatrics · 2026Article
- A Bayesian life-course linear structural equations model (BLSEM) to explore the development of body mass index (BMI) from the prenatal stage until middle age.International journal of obesity (2005) · 2025Article
- Prognostic value of hemoglobin-to-red cell distribution width ratio in patients with thoracoabdominal aortic aneurysm: a MIMIC-IV database-based retrospective study.Journal of thoracic disease · 2025Article
- Unraveling the Mystery of Hemoglobin in Hypoxia-Accelerated Neurodegenerative Diseases.Biomolecules · 2025Review
- Identification of diagnostic biomarkers and dissecting immune microenvironment with crosstalk genes in the POAG and COVID-19 nexus.Scientific reports · 2025Article
- Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia.eLife · 2025Article
- Higher hemoglobin levels are associated with adverse heart rate variability in a middle-aged birth cohort.Physiological reports · 2025Article
- Multiomics and Systematic Analyses Reveal the Roles of Hemoglobin and the HIF-1 Pathway in Polycystic Ovary Syndrome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Association of hemoglobin levels with metabolic traits in women with PCOS.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Impact of device variability and protocol differences on kidney function during normothermic machine perfusion: A comparative study using porcine and human kidneys.Artificial organs · 2025Article
- Recurrence of hepatocellular carcinoma in patients with high HALP score in TACE combined with ablation.Frontiers in oncology · 2025Article
- Health-Related Physical Fitness Status and Associated Factors in Breast Cancer Patients Undergoing Chemotherapy: A Cross-Sectional Study.Cancer management and research · 2025Article
- Ethanolic extract ofFrontiers in veterinary science · 2025Article
- Whole-genome resequencing to investigate the genetic diversity and mechanisms of plateau adaptation in Tibetan sheep.Journal of animal science and biotechnology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 9 institutions in 2 countries.
Juha AuvinenFaculty of Medicine, Center for Life Course Health Research, University of Oulu, 90014 Oulu, Finland.ORCID 0000-0003-2067-4056
Joona TapioBiocenter Oulu, 90014 Oulu, Finland.ORCID 0000-0002-9267-1586
Ville KarhunenFaculty of Medicine, Center for Life Course Health Research, University of Oulu, 90014 Oulu, Finland.ORCID 0000-0001-6064-1588
Johannes KettunenFaculty of Medicine, Center for Life Course Health Research, University of Oulu, 90014 Oulu, Finland.
Raisa SerpiBiocenter Oulu, 90014 Oulu, Finland.ORCID 0000-0002-8207-4673
Elitsa Y DimovaBiocenter Oulu, 90014 Oulu, Finland.ORCID 0000-0003-2745-8145
Dipender GillDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, W2 1PG London, UK.ORCID 0000-0001-7312-7078
Pasi SoininenComputational Medicine, Faculty of Medicine, University of Oulu, 90014 Oulu, Finland.
Tuija TammelinLIKES Research Center for Physical Activity and Health, 40700 Jyväskylä, Finland.ORCID 0000-0002-1771-3977
Juha MykkänenResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland.
Katri PuukkaNordLab Oulu, Medical Research Center Oulu, Oulu University Hospital and Department of Clinical Chemistry, University of Oulu, 90014 Oulu, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Emma RaitoharjuDepartment of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center - Tampere, Tampere University, Tampere, Finland.ORCID 0000-0002-7023-8706
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Health Technology, Finnish Cardiovascular Research Center - Tampere, Tampere University, Tampere, Finland.ORCID 0000-0002-2555-4427
Mika Ala-KorpelaFaculty of Medicine, Center for Life Course Health Research, University of Oulu, 90014 Oulu, Finland.ORCID 0000-0001-5905-1206
Olli T RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520 Turku, Finland.
Sirkka Keinänen-KiukaanniemiFaculty of Medicine, Center for Life Course Health Research, University of Oulu, 90014 Oulu, Finland.ORCID 0000-0003-1218-6925
Marjo-Riitta JärvelinFaculty of Medicine, Center for Life Course Health Research, University of Oulu, 90014 Oulu, Finland. peppi.koivunen@oulu.fi m.jarvelin@imperial.ac.uk.ORCID 0000-0002-2149-0630
Peppi KoivunenBiocenter Oulu, 90014 Oulu, Finland. peppi.koivunen@oulu.fi m.jarvelin@imperial.ac.uk.ORCID 0000-0002-2827-8229
Biocenter Finland · FIOulu University Hospital · FIUniversity of Eastern Finland · FITampere University · FIUniversity of Turku · FIImperial College London · GBLIKES – Foundation for Sport and Health Sciences · FISt George's, University of London · GBTampere University Hospital · FI
Funding
Genetics of cardiovascular risk factors in large founder population birth controlR01HL087679 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HIRSCHHORN, JOEL N · 2007 to 2009
$4.0MBritish Heart Foundation RE/18/4/34215Medical Research Council MR/M013138/2NHLBI NIH HHS R01 HL087679
Abstract
Activation of the hypoxia-inducible factor (HIF) pathway reprograms energy metabolism. Hemoglobin (Hb) is the main carrier of oxygen. Using its normal variation as a surrogate measure for hypoxia, we explored whether lower Hb levels could lead to healthier metabolic profiles in mice and humans (
Indexed as
HypoxiaLiverAnimalsHemoglobinsMetabolomeMiceOxygenHemoglobinsOxygen
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.