Evidence map›Paper›PMID 34261653›Full record

ArticleScience advances2021

Snake extract-laden hemostatic bioadhesive gel cross-linked by visible light.

Yicheng Guo, Ying Wang, Xiaohong Zhao, Xue Li, Quan Wang, Wen Zhong, Kibret Mequanint, Rixing Zhan, Malcolm Xing, Gaoxing Luo

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
19.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 173 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Crosslinker-freeMaterials today. Bio · 2025
    Article
  13. Article
  14. Article
  15. Trends in the Treatment of Chronic Wounds.Current medicinal chemistry · 2025
    Review
  16. Review
  17. 3D Printing-Based Hydrogel Dressings for Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  18. Article
  19. Review
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Yicheng GuoInstitute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, the Third Military Medical University (Army Medical University), Chongqing 400038, China.ORCID http://orcid.org/0000-0003-4131-0040
Ying WangInstitute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, the Third Military Medical University (Army Medical University), Chongqing 400038, China.ORCID http://orcid.org/0000-0002-0429-9551
Xiaohong ZhaoInstitute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, the Third Military Medical University (Army Medical University), Chongqing 400038, China.ORCID http://orcid.org/0000-0001-7268-2504
Xue LiInstitute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, the Third Military Medical University (Army Medical University), Chongqing 400038, China.ORCID http://orcid.org/0000-0003-2468-1149
Quan WangDepartment of Civil Engineering, Shantou University, Shantou 515063, China.
Wen ZhongDepartment of Biosystems Engineering, University of Manitoba, Winnipeg R3T 2N2, Canada.ORCID http://orcid.org/0000-0002-7957-7237
Kibret MequanintDepartment of Chemical and Biochemical Engineering and School of Biomedical Engineering, The University of Western Ontario, London N6A 5B9, Canada.ORCID http://orcid.org/0000-0002-7888-418X
Rixing ZhanInstitute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, the Third Military Medical University (Army Medical University), Chongqing 400038, China. zhanrixing@sina.com logxw@yahoo.com malcolm.xing@umanitoba.ca.ORCID http://orcid.org/0000-0001-9334-0247
Malcolm XingDepartment of Mechanical Engineering, University of Manitoba, Winnipeg R3T 2N2, Canada. zhanrixing@sina.com logxw@yahoo.com malcolm.xing@umanitoba.ca.ORCID http://orcid.org/0000-0002-3547-0462
Gaoxing LuoInstitute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, the Third Military Medical University (Army Medical University), Chongqing 400038, China. zhanrixing@sina.com logxw@yahoo.com malcolm.xing@umanitoba.ca.ORCID http://orcid.org/0000-0003-4764-3209
Army Medical University · CNUniversity of Manitoba · CAShantou University · CNWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioadhesives reduce operation time and surgical complications. However, in the presence of blood, adhesion strength is often compromised. Inspired by the blood clotting activity of snake venom, we report a visible light-induced blood-resistant hemostatic adhesive (HAD) containing gelatin methacryloyl and reptilase, which is a hemocoagulase (HC) extracted from

Identifiers

PMID34261653
PMCPMC8279511
OpenAlexW3180154893

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.