ArticleScience advances2021
Activity flow underlying abnormalities in brain activations and cognition in schizophrenia.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- An Epicenter-guided computational framework for personalized target of repetitive transcranial magnetic stimulation in schizophrenia.NeuroImage. Clinical · 2026Article
- Efficient Deep Learning Models for Predicting Individualized Task Activation From Resting-State Functional Connectivity.Human brain mapping · 2026Article
- Functional connectivity-based attractor dynamics of the human brain in rest, task, and disease.eLife · 2026Article
- Distributed cortical network dynamics of binocular convergent eye movements in humans.Network neuroscience (Cambridge, Mass.) · 2026Article
- Distance- and hierarchy-dependent functional dysconnectivity in schizophrenia and its association with cortical microstructure.NeuroImage. Clinical · 2026Article
- An event-related potential study using a cued task-switching paradigm reveals neural correlates of cognitive flexibility impairments in schizophrenia.BMC psychiatry · 2025Article
- Dynamically shifting from compositional to conjunctive brain representations supports cognitive task learning.Nature communications · 2025Article
- Functional dysconnectivity of visual and somatomotor networks yields a simple and robust biomarker for psychosis.Molecular psychiatry · 2025Article
- Exploring the transmission of cognitive task information through optimal brain pathways.PLoS computational biology · 2025Article
- Compensation or Preservation? Different Roles of Functional Lateralization in Speech Perception of Older Non-musicians and Musicians.Neuroscience bulletin · 2024Article
- Functional dysconnectivity of visual and somatomotor networks yields a simple and robust biomarker for psychosis.medRxiv : the preprint server for health sciences · 2024Article
- A multi-modal, asymmetric, weighted, and signed description of anatomical connectivity.Nature communications · 2024Article
- The Prediction of Brain Activity from Connectivity: Advances and Applications.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Increased whole-brain functional heterogeneity in psychosis during rest and task.NeuroImage. Clinical · 2024Article
- Network-level mechanisms underlying effects of transcranial direct current stimulation (tDCS) on visuomotor learning in schizophrenia.Translational psychiatry · 2023Article
- Causally informed activity flow models provide mechanistic insight into network-generated cognitive activations.NeuroImage · 2023Article
- Network-level mechanisms underlying effects of transcranial direct current stimulation (tDCS) on visuomotor learning impairments in schizophrenia.Research square · 2023Article
- Dorsal attention network activity during perceptual organization is distinct in schizophrenia and predictive of cognitive disorganization.The European journal of neuroscience · 2023Article
- Activity flow mapping over probabilistic functional connectivity.Human brain mapping · 2023Article
- TSP-GNN: a novel neuropsychiatric disorder classification framework based on task-specific prior knowledge and graph neural network.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Cognitive dysfunction is a core feature of many brain disorders, including schizophrenia (SZ), and has been linked to aberrant brain activations. However, it is unclear how these activation abnormalities emerge. We propose that aberrant flow of brain activity across functional connectivity (FC) pathways leads to altered activations that produce cognitive dysfunction in SZ. We tested this hypothesis using activity flow mapping, an approach that models the movement of task-related activity between brain regions as a function of FC. Using functional magnetic resonance imaging data from SZ individuals and healthy controls during a working memory task, we found that activity flow models accurately predict aberrant cognitive activations across multiple brain networks. Within the same framework, we simulated a connectivity-based clinical intervention, predicting specific treatments that normalized brain activations and behavior in patients. Our results suggest that dysfunctional task-evoked activity flow is a large-scale network mechanism contributing to cognitive dysfunction in SZ.
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