Evidence map›Paper›PMID 34261549›Full record

ArticleJournal of the International Neuropsychological Society : JINS2021

Initiation of Moderately Frequent Cannabis use in Adolescence and Young Adulthood is Associated with Declines in Verbal Learning and Memory: A Longitudinal Comparison of Pre- versus Post-Initiation Cognitive Performance.

Nirvi Ajmera, Paul F Collins, Hannah Weiss, Monica Luciana

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Article in Journal of the International Neuropsychological Society : JINS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nirvi AjmeraDepartment of Psychology, University of Minnesota, Minneapolis, USA.
Paul F CollinsDepartment of Psychology, University of Minnesota, Minneapolis, USA.
Hannah WeissDepartment of Psychology, University of Minnesota, Minneapolis, USA.
Monica LucianaDepartment of Psychology, University of Minnesota, Minneapolis, USA.ORCID 0000-0002-8662-8151

Funding

Adolescent Brain Development and Effects of Drug AbuseR01DA017843 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LUCIANA, MONICA · 2004 to 2008
$2.8M
Disrupted development of neural connections by alcohol initiation in adolescenceR01AA020033 · NIAAA · UNIVERSITY OF MINNESOTA · PI LUCIANA, MONICA · 2011 to 2015
$2.7M
NIAAA NIH HHS R01 AA020033NIDA NIH HHS R01 DA017843
6 · The paper itself

Abstract

objectiveCannabis use is associated with relative cognitive weaknesses as observed by cross-sectional as well as longitudinal research. Longitudinal studies, controlling for relevant confounds, are necessary to differentiate premorbid from post-initiation contributions to these effects.

methodsWe followed a sample of adolescents and young adults across ten years. Participants provided neurocognitive data and substance use information at two-year intervals. Participants who initiated cannabis and/or alcohol use were identified (n = 86) and split into alcohol-only initiators (n = 39) and infrequent (n = 29) and moderately frequent (n = 18) cannabis initiators. Participants completed the Rey Auditory Verbal Learning Task (RAVLT) and the Iowa Gambling Task (IGT). Group differences before and after substance use initiation and the extent to which alcohol, nicotine, and cannabis use frequencies contributed to cognitive functions over time were examined.

resultsAfter controlling for parental education, RAVLT new learning was worse in moderately frequent cannabis users prior to use initiation. RAVLT total learning and delayed recall showed significant declines from pre- to post-initiation in moderately frequent cannabis users. Regression analyses confirmed that frequencies of cannabis, but not alcohol, use contributed to post-initiation variations. Nicotine use showed an independent negative association with delayed memory. Findings for the IGT were not significant.

conclusionsVerbal learning and memory may be disrupted following the initiation of moderately frequent cannabis use while decreased new learning may represent a premorbid liability. Our use of a control group of alcohol-only users adds interpretive clarity to the findings and suggests that future studies should carefully control for comorbid substance use.

Indexed as

CannabisMarijuana AbuseAdolescentAdultCognitionCross-Sectional StudiesHumansNeuropsychological TestsVerbal LearningYoung AdultAdolescenceCannabisDecision-makingSubstance useVerbal memoryWorking memory

Identifiers

PMID34261549
PMCPMC8486043

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.