Evidence map›Paper›PMID 34261548›Full record

ArticleJournal of the International Neuropsychological Society : JINS2021

Differential Cognitive Performance in Females and Males with Regular Cannabis Use.

Ashley M Schnakenberg Martin, Deepak Cyril D'Souza, Sharlene D Newman, William P Hetrick, Brian F O'Donnell

Abstract read
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ashley M Schnakenberg MartinDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, Bloomington, Indiana, USA.ORCID 0000-0003-0320-3009
Deepak Cyril D'SouzaDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Sharlene D NewmanDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, Bloomington, Indiana, USA.
William P HetrickDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, Bloomington, Indiana, USA.
Brian F O'DonnellDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, Bloomington, Indiana, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Cerebellar timing dysfunction in schizophreniaR01MH074983 · NIMH · TRUSTEES OF INDIANA UNIVERSITY · PI HETRICK, WILLIAM P · 2006 to 2016
$3.6M
INTEGRATIVE PREDOCTORAL TRAINING IN DRUG ABUSE RESEARCH AT INDIANA UNIVERSITYT32DA024628 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI Andrea Grace Hohmann, Kenneth Mackie · 2008 to 2026
$3.1M
Cerebellar biobehavioral markers in cannabis usersR01DA048012 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI HETRICK, WILLIAM P · 2019 to 2023
$2.7M
Graph Theoretic Analysis of Brain Networks in Cannabis UsersR21DA035493 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI O'DONNELL, BRIAN FRANCIS · 2014 to 2015
$426k
NCATS NIH HHS UL1 TR001863NIDA NIH HHS R01 DA048012NIDA NIH HHS R21 DA035493NIDA NIH HHS T32 DA024628NIMH NIH HHS R01 MH074983
6 · The paper itself

Abstract

objectivesPreclinical and clinical studies suggest that males and females may be differentially affected by cannabis use. This study evaluated the interaction of cannabis use and biological sex on cognition, and the association between observed cognitive deficits and features of cannabis use.

methodsCognitive measures were assessed in those with regular, ongoing, cannabis use (N = 40; 22 female) and non-using peers (N = 40; 23 female). Intelligence, psychomotor speed, and verbal working memory were measured with the Wechsler Abbreviated Scale of Intelligence, Digit Symbol Test, and Digit Span and Hopkins Verbal Learning Test, respectively. Associations between cognitive measures and cannabis use features (e.g., lifetime cannabis use, age of initiation, time since last use of cannabis, recent high-concentration tetrahydrocannabinoid exposure) were also evaluated.

resultsNo main effects of group were observed across measures. Significant interactions between group and biological sex were observed on measures of intelligence, psychomotor speed, and verbal learning, with greatest group differences observed between males with and without regular cannabis use. Psychomotor performance was negatively correlated with lifetime cannabis exposure. Female and male cannabis use groups did not differ in features of cannabis use.

conclusionsFindings suggest that biological sex influences the relationship between cannabis and cognition, with males potentially being more vulnerable to the neurocognitive deficits related to cannabis use.

Indexed as

CannabisCognition DisordersCognitionHumansMemory, Short-TermNeuropsychological TestsVerbal LearningCannabisCognitionIntelligencePsychomotor speedSex differencesVerbal learning

Identifiers

PMID34261548
PMCPMC8830784

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.