ReviewNeurodegenerative disease management2021
Neurophysiological biomarkers to optimize deep brain stimulation in movement disorders.
Review in Neurodegenerative disease management, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06716983 (Multimodal Investigation of Cortico-Basal Ganglia-Thalamo-Cortical), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multimodal Investigation of Cortico-Basal Ganglia-Thalamo-Cortical (CBGTC) Network Dynamics in Dystonic Patients With Deep Brain Stimulation (DBS)
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Basal ganglia neurophysiological markers of non-motor symptoms in Parkinson's disease: A systematic review.Journal of Parkinson's disease · 2026Pooled it
- Lateralized Subthalamic Stimulation for Axial Dysfunction in Parkinson's Disease: Exploratory Outcomes and Open-Label Extension.Movement disorders clinical practice · 2024Trial
- ANA Investigates: Adaptive Deep Brain Stimulation.Annals of neurology · 2026Article
- Local Field Potentials in Movement Disorders: A Narrative Review.Stereotactic and functional neurosurgery · 2026Review
- Review
- Locally adapting digital health technologies to address the global challenge of Parkinson's disease.Equity neuroscience · 2025Article
- Modeling and optimizing deep brain stimulation to enhance gait in Parkinson's disease: personalized treatment with neurophysiological insights.NPJ Parkinson's disease · 2025Article
- Comparison of oscillatory activity in substantia nigra pars reticulata between Parkinson's disease and dystonia.NPJ Parkinson's disease · 2025Article
- Closing the loop in DBS: A data-driven approach.Parkinsonism & related disorders · 2025Review
- Subthalamic Nucleus Oscillatory Characteristics in Meige, Cervical Dystonia and Generalized Dystonia.Annals of clinical and translational neurology · 2025Article
- Sensing data and methodology from the Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) clinical trial.NPJ Parkinson's disease · 2024Article
- A Computational Model of Deep Brain Stimulation for Parkinson's Disease Tremor and Bradykinesia.Brain sciences · 2024Article
- Unraveling the threads of stability: A review of the neurophysiology of postural control in Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Review
- Pallidal Recordings in Chronically Implanted Dystonic Patients: Mitigation of Tremor-Related Artifacts.Bioengineering (Basel, Switzerland) · 2023Article
- Case report: Clinical efficacy of deep brain stimulation contacts corresponds to local field potential signals in a patient with obsessive-compulsive disorder.Frontiers in psychiatry · 2023Article
- Proceedings of the 10th annual deep brain stimulation think tank: Advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics, interventional psychiatry, and women in neuromodulation.Frontiers in human neuroscience · 2022Article
- Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury.Frontiers in human neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Intraoperative neurophysiological information could increase accuracy of surgical deep brain stimulation (DBS) lead placement. Subsequently, DBS therapy could be optimized by specifically targeting pathological activity. In Parkinson's disease, local field potentials (LFPs) excessively synchronized in the beta band (13-35 Hz) correlate with akinetic-rigid symptoms and their response to DBS therapy, particularly low beta band suppression (13-20 Hz) and high frequency gamma facilitation (35-250 Hz). In dystonia, LFPs abnormally synchronize in the theta/alpha (4-13 Hz), beta and gamma (60-90 Hz) bands. Phasic dystonic symptoms and their response to DBS correlate with changes in theta/alpha synchronization. In essential tremor, LFPs excessively synchronize in the theta/alpha and beta bands. Adaptive DBS systems will individualize pathological characteristics of neurophysiological signals to automatically deliver therapeutic DBS pulses of specific spatial and temporal parameters.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.