ArticleNature2021
cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila.
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Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
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113citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
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Who cites it
113 citing papers in PubMed, 186 citations in OpenAlex.
- STING agonist profiling by nucleotide library defines structural determinants of cyclic dinucleotide recognition.iScience · 2026Article
- Convergent evolution of viral nucleases targeting cyclic dinucleotides.PLoS pathogens · 2026Review
- CBASS limits bacteriophage production while maintaining cell viability in Pseudomonas aeruginosa.Cell host & microbe · 2026Article
- Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING.Immunity · 2026Article
- Is a Commensal Here, a Pathogen There? Genotype Specific Responses by the Sea Anemone Nematostella vectensis to Vibrio Species.Molecular ecology · 2026Article
- Review
- Structural genomics sheds light on protein functions and remote homologs across the insect tree of life.Cell research · 2026Article
- FADD is recruited to activated STING oligomers to initiate caspase-mediated NF-κB activation in Drosophila melanogaster.The EMBO journal · 2026Article
- cGAS knockout inhibited endotoxin-induced uveitis in mice.Genes & diseases · 2026Article
- CBASS limits bacteriophage production while maintaining cell viability inbioRxiv : the preprint server for biology · 2026Article
- STING agonist diABZI confers protection against swine acute diarrhea syndrome coronavirus in neonatal mice by activating antiviral immunity.Journal of virology · 2026Article
- Crustacean Mab21 proteins drive tissue-specific antiviral immunity by activating IKKε outside the canonical nucleic-acid sensing paradigm.PLoS pathogens · 2026Article
- Article
- A recurrent adaptive mutation in the transmembrane 2B protein of an insect picorna-like virus in a nonnative host.Journal of virology · 2026Article
- Manipulation of the nucleotide pool in human, bacterial and plant immunity.Nature reviews. Immunology · 2026Review
- Research progress on the mechanisms of cGAS-STING signaling in immune cell infiltration associated with vascular remodeling.Journal of translational medicine · 2025Review
- Advances and Strategies in Enhancing mRNA Cancer Vaccines.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- The pathogen effector BcSSP2 suppresses the NPC phase separation to facilitate Botrytis cinerea infection.Nature communications · 2025Article
- A choanoflagellate cGLR-STING pathway reveals evolutionary links between bacterial and animal immunity.bioRxiv : the preprint server for biology · 2025Article
- Nucleic Acid Diversity in cGAS-STING Pathway Activation and Immune Dysregulation.Biomedicines · 2025Review
53 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 4 institutions in 4 countries.
Kailey M SlavikDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Benjamin R MorehouseDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3352-5463
Adelyn E RagucciDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Wen ZhouDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Xianlong AiSino-French Hoffmann Institute, State Key Laboratory of Respiratory Disease, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, China.
Yuqiang ChenSino-French Hoffmann Institute, State Key Laboratory of Respiratory Disease, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, China.
Lihua LiSino-French Hoffmann Institute, State Key Laboratory of Respiratory Disease, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, China.
Ziming WeiSino-French Hoffmann Institute, State Key Laboratory of Respiratory Disease, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, China.
Heike BähreResearch Core Unit Metabolomics, Hannover Medical School, Hannover, Germany.
Martin KönigResearch Core Unit Metabolomics, Hannover Medical School, Hannover, Germany.
Roland SeifertResearch Core Unit Metabolomics, Hannover Medical School, Hannover, Germany.
Amy S Y LeeDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Hua CaiSino-French Hoffmann Institute, State Key Laboratory of Respiratory Disease, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, China.
Jean-Luc ImlerSino-French Hoffmann Institute, State Key Laboratory of Respiratory Disease, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, China.
Philip J KranzuschDepartment of Microbiology, Harvard Medical School, Boston, MA, USA. philip_kranzusch@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-4943-733X
Harvard University · USState Key Laboratory of Respiratory Disease · CNMedizinische Hochschule Hannover · DECentre National de la Recherche Scientifique · FR
Funding
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Frank V Murphy · 2018 to 2026
$34.2MUser Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6MNotice of Special Interest - R35 (Undergraduate Summer Funding)R35GM142527 · NIGMS · DANA-FARBER CANCER INST · PI LEE, AMY SI-YING · 2021 to 2025
$2.2MPixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0MPixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8MMechanism of activation of a new cGAS-like enzyme in humansF32GM133063 · NIGMS · DANA-FARBER CANCER INST · PI MOREHOUSE, BENJAMIN ROBERT · 2019 to 2020
$127kNCRR NIH HHS S10 RR029205NIGMS NIH HHS F32 GM133063NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R35 GM142527NIH HHS S10 OD021527
Abstract
Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that produces the second messenger cG[2'-5']pA[3'-5']p (2'3'-cGAMP) and controls activation of innate immunity in mammalian cells
Indexed as
Second Messenger SystemsAmino Acid SequenceAnimalsCrystallography, X-RayDrosophila melanogasterDrosophila ProteinsFemaleHumansImmunity, InnateMaleMembrane ProteinsModels, MolecularNucleotides, CyclicNucleotidyltransferasesReceptors, Pattern RecognitionRNA, Double-Strandedcyclic guanosine monophosphate-adenosine monophosphateDrosophila ProteinsMembrane ProteinsNucleotides, CyclicNucleotidyltransferasesReceptors, Pattern RecognitionRNA, Double-StrandedSTING ProteinSting protein, Drosophila
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.