Evidence map›Paper›PMID 34261097›Full record

ArticleAIDS (London, England)2021

Safety and antibody response to two-dose SARS-CoV-2 messenger RNA vaccination in persons with HIV.

Jake A Ruddy, Brian J Boyarsky, Justin R Bailey, Andrew H Karaba, Jacqueline M Garonzik-Wang, Dorry L Segev, Christine M Durand, William A Werbel

Abstract readLetter
In one paragraph

Article in AIDS (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Immunological and clinical efficacy of COVID-19 vaccines in immunocompromised populations: a systematic review.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2022
    Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Review
  8. Article
  9. Article
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  12. Article
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  14. Effects of COVID-19 mRNA vaccination on HIV viremia and reservoir size.medRxiv : the preprint server for health sciences · 2023
    Article
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jake A RuddyDepartment of Surgery.
Brian J BoyarskyDepartment of Surgery.
Justin R BaileyDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine.
Andrew H KarabaDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine.
Jacqueline M Garonzik-WangDepartment of Surgery.
Dorry L SegevDepartment of Surgery.
Christine M DurandDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine.
William A WerbelDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
HOPE in Action: A Clinical Trial of HIV-to-HIV Liver TransplantationU01AI138897 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Christine Marie Durand, DORRY L. SEGEV · 2018 to 2026
$25.5M
HOPE in Action: A clinical trial of HIV-to-HIV deceased donor kidney transplantationU01AI134591 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE, SEGEV, DORRY L. · 2017 to 2021
$11.0M
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
The Landscape of Serious Infections following Kidney Transplantation in People Living with HIVK23AI157893 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WERBEL, WILLIAM · 2021 to 2025
$847k
Aggressive Center Report Cards to Safely Increase Transplantation of Suboptimal KidneysK23DK115908 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI GARONZIK WANG, JACQUELINE M · 2018 to 2021
$516k
Aggressive Organ Procurement Organization Report Cards to Safely Increase Kidney TransplantationF32DK124941 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BOYARSKY, BRIAN · 2020 to 2020
$81k
NIAID NIH HHS K23 AI157893NIAID NIH HHS K24 AI144954NIAID NIH HHS P30 AI094189NIAID NIH HHS U01 AI134591NIAID NIH HHS U01 AI138897NIDDK NIH HHS F32 DK124941NIDDK NIH HHS K23 DK115908
6 · The paper itself

Abstract

This study of SARS-CoV-2 mRNA vaccination in 14 persons with HIV (PWH) demonstrated uniformly high anti-SARS-CoV-2 receptor binding domain (RBD) antibody titres after two doses, despite varied titres after a single dose. The majority of vaccine reactions were mild and no adverse events occurred.

Indexed as

COVID-19HIV InfectionsAntibodies, ViralAntibody FormationHumansRNA, MessengerSARS-CoV-2VaccinationAntibodies, ViralRNA, Messenger

Identifiers

PMID34261097
PMCPMC10323870

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.