Evidence map›Paper›PMID 34260938›Full record

ArticleCell reports2021

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.

Jasper E Neggers, Brenton R Paolella, Adhana Asfaw, Michael V Rothberg, Thomas A Skipper, Annan Yang, Radha L Kalekar, John M Krill-Burger, Neekesh V Dharia, Guillaume Kugener and 21 more

Abstract readPublished Erratum
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Vps4a Regulates Autophagic Flux to Prevent Hypertrophic Cardiomyopathy.International journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Jasper E Neggers
Brenton R Paolella
Adhana Asfaw
Michael V Rothberg
Thomas A Skipper
Annan Yang
Radha L Kalekar
John M Krill-Burger
Neekesh V Dharia
Guillaume Kugener
Jérémie Kalfon
Chen Yuan
Nancy Dumont
Alfredo Gonzalez
Mai Abdusamad
Yvonne Y Li
Liam F Spurr
Westley W Wu
Adam D Durbin
Brian M Wolpin
Federica Piccioni
David E Root
Jesse S Boehm
Andrew D Cherniack
Aviad Tsherniak
Andrew L Hong
William C Hahn
Kimberly Stegmaier
Todd R Golub
Francisca Vazquez
Andrew J Aguirre

Funding

Functional interrogation of epigenetic vulnerabilities in KRAS-mutant pancreatic cancerK08CA218420 · NCI · DANA-FARBER CANCER INST · PI AGUIRRE, ANDREW JAMES · 2017 to 2021
$886k
NCI NIH HHS K08 CA218420
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID34260938
PMCPMC8404147

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.