ArticleCell reports2021
Mesothelial cells are not a source of adipocytes in mice.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution.Nature metabolism · 2025Guideline
- Integrated Bulk and Single-Nucleus Transcriptomics Characterizes the Developmental and Regional Specialization of Chicken Abdominal Fat-Associated Tissue.Animals : an open access journal from MDPI · 2026Article
- Spiny Mice Show a Profibrotic Epicardial Mesothelial Response to Hypoxic Injury Comparable to C57BL/6 Mice.Biomolecules · 2026Article
- Heterogeneity and Clinical Relevance of Human Adipose Stromal and Progenitor Cells.Diabetes & metabolism journal · 2026Review
- Distinct precursor landscape of subcutaneous and visceral fat in development and aging.Cell reports · 2026Review
- Ovarian cancer metastasis to the human omentum disrupts organ homeostasis and induces fundamental tissue reprogramming.Nature communications · 2025Article
- The role of adipose tissue in critical illness-induced skeletal muscle wasting-new considerations for treatment approaches.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- Combined pharmacological targeting of CD9Cell reports. Medicine · 2025Article
- Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue.Molecular metabolism · 2025Article
- Neurotensin-neurotensin receptor 2 signaling in adipocytes suppresses food intake through regulating ceramide metabolism.Cell research · 2025Article
- Keratin 19 (Krt19) is a novel marker gene for epicardial cells.Frontiers in genetics · 2024Article
- Single-nucleus RNA sequencing reveals heterogeneity among multiple white adipose tissue depots.Life metabolism · 2023Article
- White Adipose Tissue Heterogeneity in the Single-Cell Era: From Mice and Humans to Cattle.Biology · 2023Review
- BMPER is a marker of adipose progenitors and adipocytes and a positive modulator of adipogenesis.Communications biology · 2023Article
- Circadian mechanisms in adipose tissue bioenergetics and plasticity.Genes & development · 2023Review
- Exploring the heterogeneity of white adipose tissue in mouse and man.Current opinion in genetics & development · 2023Review
- The Sexual Dimorphism of Human Adipose Depots.Biomedicines · 2022Review
- Regulation of Mesothelial Cell Fate during Development and Human Diseases.International journal of molecular sciences · 2022Review
- Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations.Nature metabolism · 2022Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Visceral adipose tissue (VAT) depots are associated with the adverse metabolic consequences of obesity, such as insulin resistance. The developmental origin of VAT depots and the identity and regulation of adipocyte progenitor cells have been active areas of investigation. In recent years, a paradigm of mesothelial cells as a source of VAT adipocyte progenitor cells has emerged based on lineage tracing studies using the Wilms' tumor gene, Wt1, as a marker for cells of mesothelial origin. Here, we show that Wt1 expression in adipose tissue is not limited to the mesothelium but is also expressed by a distinct preadipocyte population in mice and humans. We identify keratin 19 (Krt19) as a highly specific marker for the adult mouse mesothelium and demonstrate that Krt19-expressing mesothelial cells do not differentiate into visceral adipocytes. These results contradict the assertion that the VAT mesothelium can serve as a source of adipocytes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.