Evidence map›Paper›PMID 34260889›Full record

ReviewJournal of cardiac failure2022

Sarcoidosis-Related Cardiomyopathy: Current Knowledge, Challenges, and Future Perspectives State-of-the-Art Review.

Nisha A Gilotra, Jan M Griffin, Noelle Pavlovic, Brian A Houston, Jessica Chasler, Colleen Goetz, Jonathan Chrispin, Michelle Sharp, Edward K Kasper, Edward S Chen and 4 more

Open access · greenAbstract readReview
In one paragraph

Review in Journal of cardiac failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Sex differences in cardiac sarcoidosis.International journal of cardiology. Heart & vasculature · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 2 countries.

Nisha A GilotraAdvanced Heart Failure/Transplant Cardiology Section, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: naggarw2@jhmi.ed.
Jan M GriffinAdvanced Heart Failure/Transplant Cardiology Section, Division of Cardiology, Columbia University School of Medicine, New York, New York.
Noelle PavlovicJohns Hopkins University School of Nursing, Baltimore, Maryland.
Brian A HoustonAdvanced Heart Failure/Transplant Cardiology Section, Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.
Jessica ChaslerDepartment of Pharmacy, Johns Hopkins Hospital, Baltimore, Maryland.
Colleen GoetzInfiltrative Cardiomyopathy and Advanced Heart Failure Programs, MedStar Heart and Vascular Institute, Georgetown University, Washington, DC.
Jonathan ChrispinClinical Cardiac Electrophysiology Section, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Michelle SharpDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Edward K KasperAdvanced Heart Failure/Transplant Cardiology Section, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Edward S ChenDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Ron BlanksteinDepartments of Medicine (Cardiovascular Division) and Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Leslie T CooperDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, Florida.
Emer JoyceDepartment of Cardiology, Mater Misericordiae University Hospital and University College Dublin School of Medicine, Dublin, Ireland.
Farooq H SheikhInfiltrative Cardiomyopathy and Advanced Heart Failure Programs, MedStar Heart and Vascular Institute, Georgetown University, Washington, DC.
Johns Hopkins University · USGeorgetown University · USBrigham and Women's Hospital · USColumbia University · USJacksonville College · USJohns Hopkins Hospital · USMedical University of South Carolina · USUniversity College Dublin · IE

Funding

Interdisciplinary Training in Cardiovascular Health ResearchT32NR012704 · NINR · JOHNS HOPKINS UNIVERSITY · PI ALLEN, JERILYN K · 2011 to 2020
$1.8M
Medication Adherence and Clinical Outcomes in SarcoidosisK23HL148527 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SHARP, MICHELLE · 2021 to 2025
$886k
NHLBI NIH HHS K23 HL148527NINR NIH HHS T32 NR012704
6 · The paper itself

Abstract

The prevalence of sarcoidosis-related cardiomyopathy is increasing. Sarcoidosis impacts cardiac function through granulomatous infiltration of the heart, resulting in conduction disease, arrhythmia, and/or heart failure. The diagnosis of cardiac sarcoidosis (CS) can be challenging and requires clinician awareness as well as differentiation from overlapping diagnostic phenotypes, such as other forms of myocarditis and arrhythmogenic cardiomyopathy. Clinical manifestations, extracardiac involvement, histopathology, and advanced cardiac imaging can all lend support to a diagnosis of CS. The mainstay of therapy for CS is immunosuppression; however, no prospective clinical trials exist to guide management. Patients may progress to developing advanced heart failure or ventricular arrhythmia, for which ventricular assist device therapies or heart transplantation may be considered. The existing knowledge gaps in CS call for an interdisciplinary approach to both patient care and future investigation to improve mechanistic understanding and therapeutic strategies.

Indexed as

CardiomyopathiesHeart FailureHeart TransplantationMyocarditisSarcoidosisHumanscardiac sarcoidosisheart transplantationinflammatory cardiomyopathyinterdisciplinarymyocarditis

Identifiers

PMID34260889
PMCPMC8748280
OpenAlexW3180276185

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.