Evidence map›Paper›PMID 34260706›Full record

Observational studyThe journals of gerontology. Series A, Biological sciences and medical sciences2022

Cohort Analysis of the Association of Delirium Severity With Cerebrospinal Fluid Amyloid-Tau-Neurodegeneration Pathologies.

Margaret Parker, Marissa White, Cameron Casey, David Kunkel, Amber Bo, Kaj Blennow, Henrik Zetterberg, Robert A Pearce, Richard Lennertz, Robert D Sanders

Registry-linked trialOpen access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02926417 (Interventions for Postoperative Delirium), which is not on this map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02926417 completednot on this map

Interventions for Postoperative Delirium: Biomarker-2 (IPOD-B2) Pilot Study

TypeobservationalSponsorUniversity of Wisconsin, MadisonRan2016 to 2019Enrolled32ConditionsDeliriumArmsHigh Density-Electroencephalogram
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 4 countries.

Margaret ParkerDepartment of Anesthesiology, University of Wisconsin, Madison, USA.
Marissa WhiteDepartment of Anesthesiology, University of Wisconsin, Madison, USA.ORCID 0000-0003-1752-5703
Cameron CaseyDepartment of Anesthesiology, University of Wisconsin, Madison, USA.
David KunkelDepartment of Anesthesiology, University of Wisconsin, Madison, USA.ORCID 0000-0003-1812-8312
Amber BoDepartment of Anesthesiology, University of Wisconsin, Madison, USA.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID 0000-0003-3930-4354
Robert A PearceDepartment of Anesthesiology, University of Wisconsin, Madison, USA.
Richard LennertzDepartment of Anesthesiology, University of Wisconsin, Madison, USA.
Robert D SandersSchool of Medicine, University of Sydney, New South Wales, Australia.ORCID 0000-0003-0113-0328
University of Wisconsin–Madison · USSahlgrenska University Hospital · SEThe University of Sydney · AU

Funding

Clarifying the overlapping pathology of delirium and dementiaR01AG063849 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Richard C Lennertz, Robert D Sanders · 2019 to 2026
$5.0M
Alzheimer's Association #ADSF-21-831376-CEuropean Research Council #681712Marie Curie 860197NIA NIH HHS R01 AG063849NIH HHS R01AG063849
6 · The paper itself

Abstract

Delirium is associated with cognitive decline and subsequent dementia, and rises in plasma total tau (tTau) and neurofilament light (NfL), providing links to Amyloid-Tau-Neurodegeneration (ATN) pathophysiology. We investigated whether changes in delirium severity after surgery correlated with changes in cerebrospinal fluid (CSF) ATN biomarkers. Thirty-two thoracic vascular surgical patients were recruited into a prospective biomarker cohort study with assessment of delirium severity and incidence (NCT02926417). CSF (n = 54) and plasma (n = 118) samples were sent for biomarker analysis for tTau, phosphorylated tau-181 (pTau) (plasma n = 53), NfL, and amyloid-β 42/40 ratio (Ab42/40-ratio). The primary outcome was the correlation of preoperative to postoperative change in ATN biomarkers with the highest postoperative Delirium Rating Scale-98 score. CSF and plasma biomarkers all increased postoperatively (all p < .05, n = 13 paired preoperative-postoperative samples). Delirium severity was associated with peak changes in CSF tTau (p = .007, r = .710) and pTau (p = .01, r = .667) but not NfL (p = .09, ρ = .491) or Ab42/40-ratio (p = .18, ρ = .394). Sensitivity analysis with exclusion of participants with putative spinal cord ischemia shifted the NfL result to significance (p < .001, ρ = .847). Our data show that changes in tau and biomarkers of neurodegeneration in the CSF are associated with delirium severity. These data should be considered hypothesis-generating and future studies should identify if these changes are robust to confounding.

Indexed as

Alzheimer DiseaseDeliriumAmyloid beta-PeptidesAmyloidogenic ProteinsBiomarkersCohort StudiesHumansProspective Studiestau ProteinsAmyloid beta-PeptidesAmyloidogenic ProteinsBiomarkerstau ProteinsBiology of agingBiomarkersDementia

Identifiers

PMID34260706
PMCPMC9122751
OpenAlexW3180414050

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.