ArticlePLoS genetics2021
CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the Caenorhabditis elegans germ line.Development (Cambridge, England) · 2026Article
- Sensory integration of food and population density during the diapause exit decision involves insulin-like signaling inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Sensory integration of food availability and population density during the diapause exit decision involves insulin-like signaling inbioRxiv : the preprint server for biology · 2024Article
- Transcriptional and spatiotemporal regulation of the dauer program.Transcription · 2023Review
- The molecular mechanisms of diapause and diapause-like reversible arrest.Biochemical Society transactions · 2023Review
- Expression of thioredoxin-1 in the ASJ neuron corresponds with and enhances intrinsic regenerative capacity under lesion conditioning in C. elegans.FEBS letters · 2023Article
- Molecular encoding of stimulus features in a single sensory neuron type enables neuronal and behavioral plasticity.Current biology : CB · 2023Article
- Nematode Pheromones: Structures and Functions.Molecules (Basel, Switzerland) · 2023Review
- Molecular encoding of stimulus features in a single sensory neuron type enables neuronal and behavioral plasticity.bioRxiv : the preprint server for biology · 2023Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Animals can adapt to dynamic environmental conditions by modulating their developmental programs. Understanding the genetic architecture and molecular mechanisms underlying developmental plasticity in response to changing environments is an important and emerging area of research. Here, we show a novel role of cAMP response element binding protein (CREB)-encoding crh-1 gene in developmental polyphenism of C. elegans. Under conditions that promote normal development in wild-type animals, crh-1 mutants inappropriately form transient pre-dauer (L2d) larvae and express the L2d marker gene. L2d formation in crh-1 mutants is specifically induced by the ascaroside pheromone ascr#5 (asc-ωC3; C3), and crh-1 functions autonomously in the ascr#5-sensing ASI neurons to inhibit L2d formation. Moreover, we find that CRH-1 directly binds upstream of the daf-7 TGF-β locus and promotes its expression in the ASI neurons. Taken together, these results provide new insight into how animals alter their developmental programs in response to environmental changes.
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