Evidence map›Paper›PMID 34260413›Full record

ArticleAging2021

Fibroblastic galectin-1-fostered invasion and metastasis are mediated by TGF-β1-induced epithelial-mesenchymal transition in gastric cancer.

Xiaolan You, Jian Wu, Xiaojun Zhao, Xingyu Jiang, Wenxuan Tao, Zhiyi Chen, Chuanjiang Huang, Tingrui Zheng, Xianhe Shen

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 37 citations in OpenAlex.

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  19. CD201Nature · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Xiaolan YouDepartment of Gastrointestinal Surgery, Taizhou Clinical Medical School of Nanjing Medical University (Taizhou People's Hospital), Taizhou 225300, Jiangsu, China.
Jian WuDepartment of Gastrointestinal Surgery, Taizhou Clinical Medical School of Nanjing Medical University (Taizhou People's Hospital), Taizhou 225300, Jiangsu, China.
Xiaojun ZhaoDepartment of Gastrointestinal Surgery, Taizhou Clinical Medical School of Nanjing Medical University (Taizhou People's Hospital), Taizhou 225300, Jiangsu, China.
Xingyu JiangDepartment of Clinical Speciality, Nanjing Medical University, Nanjing 210009, Jiangsu, China.
Wenxuan TaoDepartment of Clinical Speciality, Southeast University, Nanjing 210009, Jiangsu, China.
Zhiyi ChenDepartment of Gastrointestinal Surgery, Taizhou Clinical Medical School of Nanjing Medical University (Taizhou People's Hospital), Taizhou 225300, Jiangsu, China.
Chuanjiang HuangDepartment of Gastrointestinal Surgery, Taizhou Clinical Medical School of Nanjing Medical University (Taizhou People's Hospital), Taizhou 225300, Jiangsu, China.
Tingrui ZhengDepartment of Gastrointestinal Surgery, Taizhou Clinical Medical School of Nanjing Medical University (Taizhou People's Hospital), Taizhou 225300, Jiangsu, China.
Xianhe ShenDepartment of Gastrointestinal Surgery, Taizhou Clinical Medical School of Nanjing Medical University (Taizhou People's Hospital), Taizhou 225300, Jiangsu, China.
Northern Jiangsu People's Hospital · CNNantong University · CNNanjing Medical University · CNSoutheast University · CNTaizhou People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background The gastric cancer (GC) microenvironment has important effects on biological behaviors, such as tumor cell invasion and metastasis. However, the mechanism by which the GC microenvironment promotes GC cell invasion and metastasis is unknown. The present study aimed to clarify the effects and mechanism of galectin-1 (GAL-1, encoded by

Indexed as

AdultAgedAged, 80 and overCancer-Associated FibroblastsCell Line, TumorCell MovementEpithelial-Mesenchymal TransitionFemaleGalectin 1Gene Expression Regulation, NeoplasticHumansMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPrognosisGalectin 1LGALS1 protein, humanSmad3 ProteinTGFB1 protein, humanTransforming Growth Factor beta1cancer-associated fibroblastsepithelial-mesenchymal transitiongalectin-1gastric cancer microenvironmentTGF-β1/Smad signaling pathway

Identifiers

PMID34260413
PMCPMC8351703
OpenAlexW3182184901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.