ArticleProceedings of the National Academy of Sciences of the United States of America2021
Thousands of induced germline mutations affecting immune cells identified by automated meiotic mapping coupled with machine learning.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
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Who cites it
16 citing papers in PubMed, 16 citations in OpenAlex.
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- PPa1 insufficiency drives lysosomal storage disease and inflammatory macrophage expansion in the bone marrow.bioRxiv : the preprint server for biology · 2026Article
- A hypomorphic Mpi mutation unlocks an in vivo tool for studying global N-glycosylation deficiency.JCI insight · 2025Article
- The Rab32-LRMDA-Retriever Complex is a Key Regulator of Intestinal Immune Homeostasis.bioRxiv : the preprint server for biology · 2025Article
- Nonredundant Role of Leishmanolysin-Like (Lmln) Zinc-Metallopeptidase in Retinal Homeostasis.American journal of ophthalmology · 2025Article
- Suppression of melanoma by mice lacking MHC-II: Mechanisms and implications for cancer immunotherapy.The Journal of experimental medicine · 2024Article
- Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity.EMBO reports · 2024Article
- Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Deep Learning-Based Automated Measurement of Murine Bone Length in Radiographs.Bioengineering (Basel, Switzerland) · 2024Article
- Viable mutations of mouse midnolin suppress B cell malignancies.The Journal of experimental medicine · 2024Article
- Genetic influences on motor learning and performance and superperforming mutants revealed by random mutational survey of the mouse genome.The Journal of physiology · 2024Article
- Genetic determinants of blood pressure and heart rate identified through ENU-induced mutagenesis with automated meiotic mapping.Science advances · 2024Article
- E3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegeneration.Scientific reports · 2024Article
- Essential requirement for IER3IP1 in B cell development.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis.Communications biology · 2023Article
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Authors and funding
55 authors at 2 institutions in 1 country.
Darui XuCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-1117-966X
Stephen LyonCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-6198-3827
Chun Hui BuCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Sara HildebrandCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-5534-3604
Jin Huk ChoiCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-2483-4379
Xue ZhongCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Aijie LiuCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Emre E TurerCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Zhao ZhangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-9345-3663
Jamie RussellCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-9090-4067
Sara LudwigCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Elena MahrtCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Evan Nair-GillCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Hexin ShiCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Ying WangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Duanwu ZhangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Tao YueCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Kuan-Wen WangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Jeffrey A SoRelleCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Lijing SuCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Takuma MisawaCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
William McAlpineCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Lei SunCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Jianhui WangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Xiaoming ZhanCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Mihwa ChoiCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Roxana FarokhniaCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Andrew SaklaCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Sara SchneiderCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-6277-1578
Hannah CocoCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Gabrielle CoolbaughCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Braden HayseCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Sara MazalCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Dawson MedlerCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-7282-3805
Brandon NguyenCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Edward RodriguezCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Andrew WadleyCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Miao TangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Xiaohong LiCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0001-8357-5587
Priscilla AndertonCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Katie KellerCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Amanda PressCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Lindsay ScottCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-4243-4010
Jiexia QuanCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-4762-3833
Sydney CooperCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Tiffany CollieCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Baifang QinCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Jennifer CardinCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Rochelle SimpsonCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Meron TadesseCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Qihua SunCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Carol A WiseCenter for Pediatric Bone Biology and Translational Research, Scottish Rite for Children, Dallas, TX 75219.
Jonathan J RiosCenter for Pediatric Bone Biology and Translational Research, Scottish Rite for Children, Dallas, TX 75219.
Eva Marie Y MorescoCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-2049-7291
Bruce BeutlerCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390; Bruce.Beutler@UTSouthwestern.edu.ORCID 0000-0002-3639-246X
The University of Texas Southwestern Medical Center · USTexas Scottish Rite Hospital for Children · US
Funding
Systems Biology CoreU19AI100627 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI NOLAN, GARRY P · 2012 to 2021
$49.1MAutomated Forward Genetic Analysis of Adaptive ImmunityR01AI125581 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI BRUCE A BEUTLER · 2016 to 2026
$19.5MINTEGRATIVE IMMUNOLOGY TRAINING PROGRAMT32AI005284 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Nan Yan · 2003 to 2026
$7.4MThe Role of the Smcr8-Wdr41-C9orf72 (SWC) Complex in the Maintenance of Intestinal HomeostasisR01DK119360 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI TURER, EMRE EROL · 2020 to 2023
$1.8MThe Role of KBTBD2 in Lipodystrophy, Insulin Resistance, and DiabetesR00DK115766 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI ZHANG, ZHAO · 2020 to 2022
$747kControl of Dendritic Cell Function by the Lipopolysaccharide (LPS)-Responsive and Beige-like Anchor protein (Lrba)R03DK125631 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI TURER, EMRE EROL · 2020 to 2021
$246kNIAID NIH HHS R01 AI125581NIAID NIH HHS T32 AI005284NIAID NIH HHS U19 AI100627NIDDK NIH HHS R00 DK115766NIDDK NIH HHS R01 DK119360NIDDK NIH HHS R03 DK125631
Abstract
Forward genetic studies use meiotic mapping to adduce evidence that a particular mutation, normally induced by a germline mutagen, is causative of a particular phenotype. Particularly in small pedigrees, cosegregation of multiple mutations, occasional unawareness of mutations, and paucity of homozygotes may lead to erroneous declarations of cause and effect. We sought to improve the identification of mutations causing immune phenotypes in mice by creating Candidate Explorer (CE), a machine-learning software program that integrates 67 features of genetic mapping data into a single numeric score, mathematically convertible to the probability of verification of any putative mutation-phenotype association. At this time, CE has evaluated putative mutation-phenotype associations arising from screening damaging mutations in ∼55% of mouse genes for effects on flow cytometry measurements of immune cells in the blood. CE has therefore identified more than half of genes within which mutations can be causative of flow cytometric phenovariation in
Indexed as
Machine LearningAlgorithmsAnimalsAutomationFemaleFlow CytometryGerm-Line MutationLeukocytesMaleMeiosisMiceMice, Inbred C57BLPhenotypeProbabilityReproducibility of ResultsSoftwareautomated meiotic mappingENU mutagenesisflow cytometryimmune cellsmachine learning
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