Evidence map›Paper›PMID 34260396›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Let-7b-5p in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic sensitivity of

Katja Koeppen, Amanda Nymon, Roxanna Barnaby, Laura Bashor, Zhongyou Li, Thomas H Hampton, Amanda E Liefeld, Fred W Kolling, Ian S LaCroix, Scott A Gerber and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 58 citations in OpenAlex.

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  10. Article
  11. Mesenchymal stromal cell extracellular vesicles reduceAmerican journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  12. Review
  13. Let-7b-5p loaded Mesenchymal Stromal Cell Extracellular Vesicles reducebioRxiv : the preprint server for biology · 2025
    Article
  14. Article
  15. Review
  16. Article
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  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Katja KoeppenDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755; Katja.Koeppen@Dartmouth.edu.ORCID 0000-0003-1094-0621
Amanda NymonDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
Roxanna BarnabyDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
Laura BashorDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.ORCID 0000-0002-8609-1219
Zhongyou LiDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.ORCID 0000-0002-0196-2979
Thomas H HamptonDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.ORCID 0000-0003-0543-402X
Amanda E LiefeldDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.
Fred W KollingNorris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756.ORCID 0000-0002-6178-9901
Ian S LaCroixNorris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756.
Scott A GerberNorris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756.
Deborah A HoganDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.ORCID 0000-0002-6366-2971
Swetha KasettyDepartment of Biological Sciences, Dartmouth College, Hanover, NH 03755.ORCID 0000-0001-7199-3239
Carey D NadellDepartment of Biological Sciences, Dartmouth College, Hanover, NH 03755.ORCID 0000-0003-1751-4895
Bruce A StantonDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755.ORCID 0000-0002-1661-407X
Dartmouth College · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MIERKE, DALE F · 2016 to 2025
$25.9M
Translational Research CoreP30DK117469 · NIDDK · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 2018 to 2026
$13.9M
Hypoxia Adaptation and Fungal Virulence of Aspergillus fumigatusR01AI081838 · NIAID · MONTANA STATE UNIVERSITY - BOZEMAN · PI CRAMER, ROBERT ANDREW · 2009 to 2017
$2.9M
Retrieval, Reprocessing, Normalization and Sharing of Gene Expression and Lung Microbiome Data Sets to Facilitate AI/ML Analysis Studies of Bacterial Lung InfectionsR01HL151385 · NHLBI · DARTMOUTH COLLEGE · PI STANTON, BRUCE A. · 2021 to 2024
$2.4M
CSU Infectious Disease Research and Response Training ProgramT32AI162691 · NIAID · COLORADO STATE UNIVERSITY · PI DEAN, GREGG A · 2021 to 2025
$2.1M
Reproducible and FAIR Bioinformatics Analysis of Omics DataR25HG011447 · NHGRI · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI HAMPTON, THOMAS H, STANTON, BRUCE A. · 2021 to 2025
$399k
NCI NIH HHS P30 CA023108NHGRI NIH HHS R25 HG011447NHLBI NIH HHS R01 HL151385NIAID NIH HHS R01 AI081838NIAID NIH HHS T32 AI162691NIDDK NIH HHS P30 DK117469NIGMS NIH HHS P20 GM113132
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AntagomirsAnti-Bacterial AgentsAztreonambeta-LactamsBiofilmsExtracellular VesiclesGene Expression Regulation, BacterialHumansMicroRNAsPlanktonPseudomonas aeruginosaAntagomirsAnti-Bacterial AgentsAztreonambeta-LactamsMicroRNAsmirnlet7 microRNA, humanairway epithelial cellsexosomesextracellular vesicleshost–pathogen communicationRNAi

Identifiers

PMID34260396
PMCPMC8285967
OpenAlexW3179826439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.