Evidence map›Paper›PMID 34260395›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Skin sodium is increased in male patients with multiple sclerosis and related animal models.

Konstantin Huhn, Peter Linz, Franziska Pemsel, Bernhard Michalke, Stefan Seyferth, Christoph Kopp, Mohammad Anwar Chaudri, Veit Rothhammer, Arnd Dörfler, Michael Uder and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Estimation of skin sodium content viaMagma (New York, N.Y.) · 2026
    Article
  3. Article
  4. An autoimmune transcriptional circuit drives FOXP3Science translational medicine · 2024
    Article
  5. QuantitativeMagma (New York, N.Y.) · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

  • Commented on by
    2021
5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Konstantin HuhnDepartment of Neurology, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.ORCID 0000-0002-6965-2117
Peter LinzDepartment of Radiology, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.ORCID 0000-0002-8232-1443
Franziska PemselDepartment of Neurology, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Bernhard MichalkeResearch Unit Analytical BioGeoChemistry, Helmholtz Zentrum München German Research Center for Environmental Health, 85764 Munich, Germany.ORCID 0000-0001-6376-2588
Stefan SeyferthDivision of Pharmaceutics, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Christoph KoppDepartment of Nephrology and Hypertension, University Hospital Erlangen, 91054 Erlangen, Germany.
Mohammad Anwar ChaudriInstitute of Corrosion and Surface Science, Department of Material Science, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Veit RothhammerDepartment of Neurology, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Arnd DörflerDepartment of Neuroradiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Michael UderDepartment of Radiology, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.ORCID 0000-0001-6238-4247
Armin M NagelDepartment of Radiology, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.ORCID 0000-0003-0948-1421
Dominik N MüllerExperimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin, 13125 Berlin, Germany.ORCID 0000-0003-3650-5644
Anne WaschbischDepartment of Neurology, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.ORCID 0000-0002-9305-1979
De-Hyung LeeDepartment of Neurology, University Hospital Regensburg, 93053 Regensburg, Germany.
Tobias BäuerleDepartment of Radiology, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Ralf A LinkerDepartment of Neurology, University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-8740-3106
Stefanie HaaseDepartment of Neurology, University Hospital Regensburg, 93053 Regensburg, Germany stefanie.haase@ukr.de.ORCID 0000-0002-9371-4314
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity Hospital Regensburg · DEGerman Cancer Research Center · DEHelmholtz Zentrum München · DEMax Delbrück Center · DEUniversitätsklinikum Erlangen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel MRI techniques allow a noninvasive quantification of tissue sodium and reveal the skin as a prominent compartment of sodium storage in health and disease. Since multiple sclerosis (MS) immunopathology is initiated in the periphery and increased sodium concentrations induce proinflammatory immune cells, the skin represents a promising compartment linking high sodium concentrations and MS immunopathology. We used a 7-T sodium MRI (

Indexed as

AdultAnimalsDisease Models, AnimalHumansInflammationMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMultiple SclerosisMultiple Sclerosis, Relapsing-RemittingSignal Processing, Computer-AssistedSkinSodiumSodiumexperimental autoimmune encephalomyelitismultiple sclerosisskinsodium magnetic resonance imaging

Identifiers

PMID34260395
PMCPMC8285971
OpenAlexW3178660612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.