ArticleProceedings of the National Academy of Sciences of the United States of America2021
A self-powered implantable and bioresorbable electrostimulation device for biofeedback bone fracture healing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 147 citations in OpenAlex.
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- Design, Implantation, and Biodistribution Study of a Resorbable Epidural Electrode Array Embedding Bioresorbable Polymeric Conductive Ink.ACS applied materials & interfaces · 2026Article
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- 3D-printed triboelectric scaffolds for fabricating BMSC-derived cartilage to repair bone defects and promote endochondral ossification.Bioactive materials · 2026Article
- Clinical Applications of Biophysical Stimuli Technologies for Bone Healing.Annals of biomedical engineering · 2026Review
- Wavy-Interlocked Stretchable Triboelectric Nanogenerators Enhanced by Liquid Metal Microflowers for Self-Powered Wearable Motion Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Emerging Triboelectric Nanogenerators for In-Body Implantation.Small methods · 2026Review
- Biomaterial-assisted neuralization strategies for tissue engineering applications.Materials today. Bio · 2026Review
- A bioabsorbable body-coupling-electrotherapy suture.Nature communications · 2025Article
- Injectable magnesium-bisphosphonate MOF-based bone adhesive prevents excessive fibrosis for osteoporotic fracture repair.Nature communications · 2025Article
- Implantable Self-Powered Systems for Electrical Stimulation Medical Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Accelerated Bone Healing via Electrical Stimulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Biodegradable and Implantable Triboelectric Nanogenerator Improved by β-Lactoglobulin Fibrils-Assisted Flexible PVA Porous Film.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Closed-eye intraocular pressure and eye movement monitoring via a stretchable bimodal contact lens.Microsystems & nanoengineering · 2025Article
- Nanostructures and Nanomaterials Integrated into Triboelectric Nanogenerators.Micromachines · 2025Review
- Research status of biomaterials based on physical signals for bone injury repair.Regenerative therapy · 2025Review
- Implantable wireless suture sensor for in situ tendon and ligament strain monitoring.Science advances · 2025Article
- Electrically Active Biomaterials for Stimulation and Regeneration in Tissue Engineering.Journal of biomedical materials research. Part A · 2025Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Electrostimulation has been recognized as a promising nonpharmacological treatment in orthopedics to promote bone fracture healing. However, clinical applications have been largely limited by the complexity of equipment operation and stimulation implementation. Here, we present a self-powered implantable and bioresorbable bone fracture electrostimulation device, which consists of a triboelectric nanogenerator for electricity generation and a pair of dressing electrodes for applying electrostimulations directly toward the fracture. The device can be attached to irregular tissue surfaces and provide biphasic electric pulses in response to nearby body movements. We demonstrated the operation of this device on rats and achieved effective bone fracture healing in as short as 6 wk versus the controls for more than 10 wk to reach the same healing result. The optimized electrical field could activate relevant growth factors to regulate bone microenvironment for promoting bone formation and bone remodeling to accelerate bone regeneration and maturation, with statistically significant 27% and 83% improvement over the control groups in mineral density and flexural strength, respectively. This work provided an effective implantable fracture therapy device that is self-responsive, battery free, and requires no surgical removal after fulfilling the biomedical intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.