Evidence map›Paper›PMID 34260310›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2021

Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease.

Nandini Girish, Cambrian Y Liu, Safina Gadeock, Marie L Gomez, Ying Huang, Zohreh Sharifkhodaei, M Kay Washington, D Brent Polk

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

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  18. Frontiers in cellular and infection microbiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nandini GirishDivision of Pediatric Gastroenterology, Hepatology, & Nutrition, Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California.
Cambrian Y LiuDivision of Pediatric Gastroenterology, Hepatology, & Nutrition, Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California.
Safina GadeockDivision of Pediatric Gastroenterology, Hepatology, & Nutrition, Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California.
Marie L GomezDepartment of Biochemistry & Molecular Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Ying HuangDivision of Pediatric Gastroenterology, Hepatology, & Nutrition, Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California.
Zohreh SharifkhodaeiDivision of Pediatric Gastroenterology, Hepatology, & Nutrition, Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California.
M Kay WashingtonDepartment of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee.
D Brent PolkDivision of Pediatric Gastroenterology, Hepatology, & Nutrition, Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California.ORCID 0000-0001-6680-1554
Children's Hospital of Los Angeles · USUniversity of Southern California · USVanderbilt University Medical Center · US

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
CYTOKINE REGULATION OF INTESTINAL EPITHELIAL RESTITUTIONR01DK056008 · NIDDK · VANDERBILT UNIVERSITY · PI POLK, D BRENT · 1999 to 2020
$6.8M
Stem Cell Dynamics in Colonic Epithelial RepairR01DK108648 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Cambrian Yangshao Liu, D Brent Polk · 2016 to 2026
$2.7M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 5R01DK056008HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 5R01DK108648HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) P30DK042086NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK056008NIDDK NIH HHS R01 DK108648
6 · The paper itself

Abstract

Intestinal mucosal healing is the primary therapeutic goal of medical treatments for inflammatory bowel disease (IBD). Epithelial stem cells are key players in the healing process. Lgr5+ stem cells maintain cellular turnover during homeostasis in the colonic crypt. However, they are lost and dispensable for repair in a wide variety of injury models, including dextran sulfate sodium (DSS) colitis, radiation, helminth infection, and T-cell activation. The direct loss of Lgr5+ cells activates a plasticity response in the epithelium in which other cell types can serve as stem cells. Whether this paradigm applies to mouse models of IBD remains unknown. In contrast to previously tested models, IBD models involve an inflammatory response rooted in the loss of immunologic tolerance to intestinal luminal contents including the microbiome. Here, we show the persistence of Lgr5+ cells in oxazolone, 2,4,6-trinitrobenzene sulfonic acid (TNBS), and

Indexed as

AnimalsCell ProliferationColitisDisease Models, AnimalEpitheliumHomeostasisInflammatory Bowel DiseasesIntestinal MucosaMiceReceptors, G-Protein-CoupledRegenerationStem CellsLgr5 protein, mouseReceptors, G-Protein-Coupledinjurymucosal healingregenerationrepairwounds

Identifiers

PMID34260310
PMCPMC8461791
OpenAlexW3181541326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.