Evidence map›Paper›PMID 34260308›Full record

ArticleApplied and environmental microbiology2021

Resident TP712 Prophage of Lactococcus lactis Strain MG1363 Provides Extra Holin Functions to the P335 Phage CAP for Effective Host Lysis.

Susana Escobedo, Udo Wegmann, Mikel Pérez de Pipaon, Ana B Campelo, Régis Stentz, Ana Rodríguez, Beatriz Martínez

Open access · greenAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Susana Escobedo *DairySafe Group. Instituto de Productos Lácteos de Asturias, IPLA-CSIC, Villaviciosa, Asturias, Spain.
Udo Wegmann *School of Chemistry, University of East Anglia, Norwich, United Kingdom.
Mikel Pérez de PipaonDairySafe Group. Instituto de Productos Lácteos de Asturias, IPLA-CSIC, Villaviciosa, Asturias, Spain.
Ana B CampeloDairySafe Group. Instituto de Productos Lácteos de Asturias, IPLA-CSIC, Villaviciosa, Asturias, Spain.
Régis StentzGut Microbes and Health Research Programme, Quadram Institute Bioscience, Norwich, United Kingdom.
Ana RodríguezDairySafe Group. Instituto de Productos Lácteos de Asturias, IPLA-CSIC, Villaviciosa, Asturias, Spain.ORCID 0000-0002-1577-9905
Beatriz MartínezDairySafe Group. Instituto de Productos Lácteos de Asturias, IPLA-CSIC, Villaviciosa, Asturias, Spain.ORCID 0000-0001-7692-1963
Instituto de Productos Lácteos de Asturias · ESQuadram Institute · GBUniversity of East Anglia · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prophages are widely present in Lactococcus lactis, a lactic acid bacterium (LAB) that plays a key role in dairy fermentations. L. lactis MG1363 is a laboratory strain used worldwide as a model LAB. Initially regarded as plasmid and prophage free, MG1363 carries two complete prophages, TP712 and MG-3. Only TP712 seems to be inducible but unable to lyse the host. Several so-called TP712 lysogens able to lyse upon prophage induction were reported in the past, but the reason for their lytic phenotype remained unknown. In this work, we describe CAP, a new P335 prophage detected in the "lytic TP712 lysogens" which had remained unnoticed. CAP is able to be excised after mitomycin C treatment, along with TP712, and able to infect L. lactis MG1363-like strains but not the lytic TP712 lysogens. Both phages cooperate for efficient host lysis. While the expression in

Indexed as

BacteriophagesBacteriolysisLactococcus lactisLysogenybacteriophage lysisendolysinholinLactococcus lactislysisprophage

Identifiers

PMID34260308
PMCPMC8432518
OpenAlexW3177882153

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.